Methylmethacrylate bone cement does not release histamine in patients undergoing prosthetic replacement of the femoral head

This study was designed to see if methyl methacrylate monomer bone cement released his tamine in 13 patients undergoing total hip replacement surgery with a cemented prosthesis, compared with seven control patients receiving a cementless porous-coated prosthesis. Blood samples for plasma concentrati...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1994-12, Vol.73 (6), p.779-781
Main Authors: MITSUHATA, H., SAITOH, J., SAITOH, K., FUKUDA, H., HIRABAYASI, Y., SHIMIZU, R., HASEGAWA, J., MATSUMOTO, S., ENZAN, K.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Complications
Complications, hypotension
Female
Hip Prosthesis
Histamine
Histamine - blood
Humans
hypotension
Medical sciences
Methylmethacrylates - adverse effects
Methylmethacrylates - chemistry
Middle Aged
Orthopaedic
Orthopedic surgery
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery, Orthopaedic
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Summary:This study was designed to see if methyl methacrylate monomer bone cement released his tamine in 13 patients undergoing total hip replacement surgery with a cemented prosthesis, compared with seven control patients receiving a cementless porous-coated prosthesis. Blood samples for plasma concentrations of histamine were obtained before the start of anaesthesia, immediately before insertion of methylmethacrylate bone cement into the shaft of the femur in the cemented fixation group or before insertion of the femoral component of the prosthesis in the cementless fixation group, and 15, 30 and 60 min after the start of implantation of the prosthesis. In both groups, changes in plasma histamine did not differ significantly from baseline before implantation of cement. There were no significant differences between groups. We conclude that methyl-methacrylate bone cement does not release his tamine during total hip replacement surgery.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/73.6.779