Inhibition of the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate in mouse skin by sphingosine sulfate

We investigated the effect of sphingosine sulfate on the induction of ODC (ornithine decarboxylase) activity by TPA (12-O-tetradecanoylphorbol-13-acetate) in mouse skin. When applied topically to the shaved skin of SENCAR mice at dosages of 10–40 μunol per animal, 30 min before the superficial appli...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1989-02, Vol.10 (2), p.379-381
Main Authors: Enkvetchakul, Boonprom, Merrill, Alfred H., Birt, Diane F.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Chemical agents
Enzyme Induction
Medical sciences
Mice
Ornithine Decarboxylase - biosynthesis
Skin - drug effects
Skin - enzymology
Sphingosine - pharmacology
Tetradecanoylphorbol Acetate - pharmacology
Time Factors
Tumors
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Summary:We investigated the effect of sphingosine sulfate on the induction of ODC (ornithine decarboxylase) activity by TPA (12-O-tetradecanoylphorbol-13-acetate) in mouse skin. When applied topically to the shaved skin of SENCAR mice at dosages of 10–40 μunol per animal, 30 min before the superficial application of 8.5 nmol of TPA, sphingosine sulfate dramatically inhibited the induction of ODC activity by the tumor promoter. Significant inhibition of TPA-induced ODC activity was observed at 4, 6 and 8 h after TPA treatment in separate studies. The results indicate that sphingosine sulfate is an effective inhibitor of ODC induction by TPA in mouse skin.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/10.2.379