Marked nitrosation by stimulation with lipopolysaccharide in ascorbic acid-deficient rats

Marked formation of N-nitrosothioproline (N-nitroso-thiazolidine-4-carboxylic acid) by stimulation with Escherichia coli lipopolysaccharide (LPS) was demonstrated in ascorbic acid-deficient mutant rats (osteogenic disorder syndrome rats; ODS rats) unable to synthesize ascorbic acid. The amounts of u...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1990-10, Vol.11 (10), p.1887-1889
Main Authors: Kosaka, Hiroaki, Tsuda, Mitsuhiro, Kurashima, Yukiko, Esumi, Hiroyasu, Terada, Nobuyuki, Ito, Yasuhiro, Uozumi, Mitsuro
Format: Article
Language:English
Subjects:
Adrenal Glands - metabolism
Animals
Ascorbic Acid - metabolism
Ascorbic Acid Deficiency - physiopathology
Ascorbic Acid Deficiency - urine
Biological and medical sciences
Body Weight
Bone Diseases, Metabolic - genetics
Carcinogenesis, carcinogens and anticarcinogens
Chemical agents
Escherichia coli
Female
Kidney - metabolism
Lipopolysaccharides - pharmacology
Liver - metabolism
Medical sciences
Nitrates - urine
Nitroso Compounds - urine
Rats
Rats, Mutant Strains
Spleen - metabolism
Thiazoles - urine
Thiazolidines
Tumors
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Summary:Marked formation of N-nitrosothioproline (N-nitroso-thiazolidine-4-carboxylic acid) by stimulation with Escherichia coli lipopolysaccharide (LPS) was demonstrated in ascorbic acid-deficient mutant rats (osteogenic disorder syndrome rats; ODS rats) unable to synthesize ascorbic acid. The amounts of urinary nitrate and N-nitrosothioproline excretion after thioproline administration was measured in ODS rats with and without ascorbic acid supplement before and after the injection of LPS. LPS caused marked increase of urinary nitrate excretion in both groups. Urinary N-nitrosothioproline excretion increased 6-fold after LPS injection in ODS rats not supplied with ascorbic acid, but supplement with ascorbic acid markedly decreased the excretion of N-nitroso-thioproline.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/11.10.1887