Studies on the anti-tumor-promoting activity of naturally occurring substances. IV. Pd-II [(+)anomalin, (+)praeruptorin B], a seselin-type coumarin, inhibits the promotion of skin tumor formation by 12-O-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated mice

• Published in: Carcinogenesis (New York) 1990-09, Vol.11 (9), p.1557-1561
• Main Authors: Nishino, Hoyoku, Okuyama, Toro, Takata, Mitsumasa, Shibata, Shoji, Tokuda, Harukuni, Takayasu, Junko, Hasegawa, Teiko, Nishino, Atsuko, Ueyama, Hisao, Iwashima, Akio
• Format: Article
• Language: English
• Subjects: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Cell Line; Chemical agents; Coumarins - pharmacology; Coumarins - therapeutic use; Drugs, Chinese Herbal - therapeutic use; Female; HeLa Cells - drug effects; HeLa Cells - metabolism; Herpesvirus 4, Human - drug effects; Herpesvirus 4, Human - growth & development; Humans; Medical sciences; Mice; Mice, Inbred ICR; Phosphates - metabolism; Phospholipids - metabolism; Skin Neoplasms - chemically induced; Skin Neoplasms - prevention & control; Tetradecanoylphorbol Acetate - toxicity; Tumors; Virus Activation - drug effects
• ISSN: 0143-3334; 1460-2180
• DOI: 10.1093/carcin/11.9.1557

Since Pd-II [(+)anomalin, (+)praeruptorin B], a seselin-type coumarin, was found to inhibit tumor promoter induced phemonenon in vitro, the effect of Pd-II on the in vivo tumorpromoting action of 12-O-tetradecanoylphorbol-13-acetate (IPA) in 7,12-dimethylbenz[a]anthracene-initiated mouse skin was investigated. Pd-II, applied 40 min before the TPA treatment, at a dose of 10 μmol/painting, completely suppressed tumor formation up to 20 weeks of tumor promotion, without any toxicity. Besides Pd-II, various antitumor-promoter coumarins were found in the traditional Chinese medicine Qian-Hu, from which Pd-II was obtained. These coumarins may be useful for the development of an effective method to prevent cancer.