Short Communication: Comparative activity of 4, 4'-diaminobiphenyl (benzidine) and its terphenyl analogue, 4, 4'-diaminoterphenyl, in two in vitro assays for potential carcinogenicity

The carcinogen 4, 4'-diaminobiphenyl (benzidine) has been compared in vitro with its terphenyl analogue 4, 4'-diaminoterphenyl using the Salmonella reverse mutation assay and the BHK cell-transformation assay. The responses observed, taken together with a consideration of chemical structur...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1980-09, Vol.1 (9), p.801-802
Main Authors: Ashby, John, Styles, Jerry, Callander, R.D.
Format: Article
Language:English
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Summary:The carcinogen 4, 4'-diaminobiphenyl (benzidine) has been compared in vitro with its terphenyl analogue 4, 4'-diaminoterphenyl using the Salmonella reverse mutation assay and the BHK cell-transformation assay. The responses observed, taken together with a consideration of chemical structures, indicate that the terphenyl compound is a potential carcinogen. These findings may contribute to an understanding of the mechanism of action of benzidine as a carcinogen.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/1.9.801