4-Chloromethylbiphenyl (4CMB): a novel mutagen and potential carcinogen

The bacterial mutagenicity and cell transforming properties of the monocyclic alkylating agent benzyl chloride have been compared with those of its biphenyl analogue, 4-chloromethylbiphenyl (4CMB), and it is apparent that the addition of the second benzene ring greatly enhances biological activity....

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Bibliographic Details
Published in:Carcinogenesis (New York) 1981, Vol.2 (1), p.33-38
Main Authors: Ashby, John, Trueman, R.W., Styles, Jerry, Penman, M.G., Paton, D.
Format: Article
Language:English
Subjects:
Aminobiphenyl Compounds - toxicity
Aniline Compounds - toxicity
Benzyl Compounds - toxicity
Biphenyl Compounds - toxicity
Carcinogens
Cell Transformation, Neoplastic - drug effects
Chemical Phenomena
Chemistry
Escherichia coli - drug effects
Mutagens
Salmonella typhimurium - genetics
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Summary:The bacterial mutagenicity and cell transforming properties of the monocyclic alkylating agent benzyl chloride have been compared with those of its biphenyl analogue, 4-chloromethylbiphenyl (4CMB), and it is apparent that the addition of the second benzene ring greatly enhances biological activity. The possible reasons for this enhancement are discussed in relation to similar effects observed when comparing the activities of aniline with its biphenyl analogue, 4-aminobiphenyl (4AB). The marked activity observed for 4CMB, a stable and crystalline solid, suggests that it could prove useful as a direct-acting positive control test chemical for use in short-term mutagenicity tests.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/2.1.33