5-Methoxypsoralen, the melanogenic additive in sun-tan preparations, is tumorigenic in mice exposed to 365 nm u.v. radiation

5-Methoxypsoralen (5 MOP), the melanogenic component present in several suntan preparations was synthesized and tested by topical applications in inbred XVII nc/Z albino mice combined with 365 nm irradiation with the aim of establishing the relative carcinogenic activity of this compound, as compare...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1981, Vol.2 (2), p.121-127
Main Authors: Zajdela, F., Bisagni, E.
Format: Article
Language:English
Subjects:
5-Methoxypsoralen
Animals
Carcinogens
Carcinoma, Squamous Cell - chemically induced
DNA Repair - drug effects
Female
Male
Methoxsalen - toxicity
Mice
Neoplasms, Radiation-Induced - physiopathology
Skin Neoplasms - chemically induced
Ultraviolet Rays
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Summary:5-Methoxypsoralen (5 MOP), the melanogenic component present in several suntan preparations was synthesized and tested by topical applications in inbred XVII nc/Z albino mice combined with 365 nm irradiation with the aim of establishing the relative carcinogenic activity of this compound, as compared to 8-methoxy-psoralen (8 MOP) and psoralen. 85% of the animals developed tumors and 25% had multiple tumors. Additional treatment with 12-O-tetradecanoylphorbol-13-acetate raised the tumor incidence to 100%. Tumors caused by 5 MOP show much longer latent periods than those induced by psoralen and 8 MOP. Most of the tumors were rapidly growing squamous cell carcinomas giving metastases in 20% of the animals. The possible long-term effects that might follow the use of 5 MOP in humans are discussed.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/2.2.121