Effect of ovarian hormones on the induction of 1-methyl-1-nitrosourea-induced mammary cancer

The concomitant administration of 20 μg 17β-estradiol and 4 mg progesterone/injection (5 days/week) over a 40-day treatment period beginning 10 days after methylnitrosourea (MNU) treatment was as effective as ovariectomy in inhibiting mammary cancers (an 84% reduction from non-hormone treated rats)....

Full description

Saved in:
Bibliographic Details
Published in:Carcinogenesis (New York) 1983, Vol.4 (4), p.495-497
Main Authors: Grubbs, Clinton J., Peckham, John C., McDonough, Karen D.
Format: Article
Language:English
Subjects:
Animals
Drug Interactions
Estradiol - pharmacology
Female
Mammary Neoplasms, Experimental - chemically induced
Mammary Neoplasms, Experimental - prevention & control
Methylnitrosourea - toxicity
Nitrosourea Compounds - toxicity
Progesterone - pharmacology
Rats
Rats, Inbred Strains
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The concomitant administration of 20 μg 17β-estradiol and 4 mg progesterone/injection (5 days/week) over a 40-day treatment period beginning 10 days after methylnitrosourea (MNU) treatment was as effective as ovariectomy in inhibiting mammary cancers (an 84% reduction from non-hormone treated rats). The primary action of the hormones must have been directed at preneoplastic cells since the hormones were not given until 10 days after MNU (a direct-acting carcinogen with a short half-life).
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/4.4.495