The growth of cultured human foreskin keratinocytes is not stimulated by a tumor promoter

The tumor promoter 12-0-tetmlecanoyl phorbol-13-acetate (TPA) does not stimulate the growth of human epidermal cells in foreskin explant cultures; a dosedependent inhibition is seen at doses higher than 10-5 µg/ml . TPA also inhibits epidermal growth factor-stimulated growth and does not induce orni...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1984-01, Vol.5 (1), p.109-112
Main Authors: Fischer, Susan M., Viaje, Aurora, Mills, Gerald D., Wong, Edith W., Weeks, Charles E., Slaga, Thomas J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Cell Division - drug effects
Cells, Cultured
Chemical agents
Epidermal Growth Factor - pharmacology
Humans
Male
Medical sciences
Ornithine Decarboxylase - metabolism
Phorbols - pharmacology
Skin - cytology
Skin - metabolism
Tetradecanoylphorbol Acetate - pharmacology
Tumors
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Summary:The tumor promoter 12-0-tetmlecanoyl phorbol-13-acetate (TPA) does not stimulate the growth of human epidermal cells in foreskin explant cultures; a dosedependent inhibition is seen at doses higher than 10-5 µg/ml . TPA also inhibits epidermal growth factor-stimulated growth and does not induce ornithine decarboxylase activity or increase potyamine levels. This is not due to the rapid breakdown of TPA, since TPA is not metabolized to any appredable extent.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/5.1.109