Effect of varying the length of exposure to polybrominated biphenyls on the development of gamma-glutamyl transpeptidase enzymealtered foci

Female Sprague-Dawley rats were fed polybrominated biphenyls (PBBs) for 15 or 140 days after a 70% partial hepatectomy and diethylnitrosamiw administration (10 mg/kg body weight) to determine the effect of varying the length of exposure to PBBs on the enhancement of gamma utamyl traospeptidase enzym...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1984-01, Vol.5 (1), p.63-66
Main Authors: Jensen, Richard K., Sleight, Stuart D., Aust, Steven D.
Format: Article
Language:English
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Summary:Female Sprague-Dawley rats were fed polybrominated biphenyls (PBBs) for 15 or 140 days after a 70% partial hepatectomy and diethylnitrosamiw administration (10 mg/kg body weight) to determine the effect of varying the length of exposure to PBBs on the enhancement of gamma utamyl traospeptidase enzyme-alted foci. fireMaster BP-6R, a cornmedal mbrture of PBBs, was fed to rats at a dietary concentration of 100 mg/kg for 15 days or 10 mg/kg for 140 days during the promotion phase of a two-stage hepatocarcinogenesis assay. Results indicate that short term exposure to PBBs is as effective as long term exposure in enhandog the development of enzyme-altered foci.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/5.1.63