Visible-light-catalyzed synthesis of amino alcohols from N , N -dimethylaniline and aryl aldehyde

Herein, we describe a direct radical addition reaction of aryl aldehyde and N, N-dimethylaniline using iridium complex as photocatalyst to form amino alcohols under mild conditions, offering a convenient and sustainable methodology. The reaction could be easily scaled up through continuous flow reac...

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Bibliographic Details
Published in:Chemistry letters 2024-06, Vol.53 (6)
Main Authors: Jin, Jia-Hui, Ma, Yi-Jian, Yin, Yu-Yun, Zhao, Fu-Gang, Shen, Cheng-Shuo, Xu, Cheng-Miao, Shen, Yong-Miao
Format: Article
Language:English
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Summary:Herein, we describe a direct radical addition reaction of aryl aldehyde and N, N-dimethylaniline using iridium complex as photocatalyst to form amino alcohols under mild conditions, offering a convenient and sustainable methodology. The reaction could be easily scaled up through continuous flow reaction with high yield. A series of amino alcohol compounds were synthesized with iridium complex as photocatalyst. The reaction could be scaled up with continuous flow reaction. The reaction mechanism has been investigated with the aid of density functional theory (DFT) calculations.
ISSN:0366-7022
1348-0715
DOI:10.1093/chemle/upae112