How Generalizable Are Randomized Controlled Trials (RCTs) in Staphylococcus aureus Bacteremia? A Description of the Mortality Gap Between RCTs and Observational Studies

In Staphylococcus aureus bacteremia, mortality rates in randomized controlled trials (RCTs) are consistently lower than observational studies. Stringent eligibility criteria and omission of early deaths in RCTs contribute to this mortality gap. Clinicians should acknowledge the possibility of a lowe...

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Bibliographic Details
Published in:Clinical infectious diseases 2022-10, Vol.75 (8), p.1449-1452
Main Authors: Bai, Anthony D, Lo, Carson K L, Komorowski, Adam S, Suresh, Mallika, Guo, Kevin, Garg, Akhil, Tandon, Pranav, Senecal, Julien, Del Corpo, Olivier, Stefanova, Isabella, Fogarty, Clare, Butler-Laporte, Guillaume, McDonald, Emily G, Cheng, Matthew P, Morris, Andrew M, Loeb, Mark, Lee, Todd C
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Bacteremia - drug therapy
Humans
Randomized Controlled Trials as Topic
Staphylococcal Infections - drug therapy
Staphylococcus aureus
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Summary:In Staphylococcus aureus bacteremia, mortality rates in randomized controlled trials (RCTs) are consistently lower than observational studies. Stringent eligibility criteria and omission of early deaths in RCTs contribute to this mortality gap. Clinicians should acknowledge the possibility of a lower treatment effect when applying RCT results to bedside care.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciac177