Preemptive Tecovirimat Use in an Active Duty Service Member Who Presented With Acute Myeloid Leukemia After Smallpox Vaccination

Abstract Smallpox vaccine is contraindicated in immunosuppression due to increased risk for adverse reactions (eg, progressive vaccinia). We describe the first-ever use of tecovirimat as a preemptive vaccinia virus treatment strategy during induction chemotherapy in an active duty service member who...

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Bibliographic Details
Published in:Clinical infectious diseases 2019-11, Vol.69 (12), p.2205-2207
Main Authors: Lindholm, David A, Fisher, Raymond D, Montgomery, Jay R, Davidson, Whitni, Yu, Patricia A, Yu, Yon C, Burgado, Jillybeth, Wilkins, Kimberly, Petersen, Brett W, Okulicz, Jason F
Format: Article
Language:English
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Summary:Abstract Smallpox vaccine is contraindicated in immunosuppression due to increased risk for adverse reactions (eg, progressive vaccinia). We describe the first-ever use of tecovirimat as a preemptive vaccinia virus treatment strategy during induction chemotherapy in an active duty service member who presented with acute leukemia and inadvertent autoinoculation after smallpox vaccination.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciz286