Infections Caused by Erythromydn-Resistant Streptococcus pneumoniae: Incidence, Risk Factors, and Response to Therapy in a Prospective Study

To evaluate the incidence and the significance of resistance to erythromycin among clinical isolates of Streptococcus pneumoniae, we identified and prospectively followed all hospitalized patients in a 27-month period who had the organism isolated from any clinical sample. Patients who had an infect...

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Bibliographic Details
Published in:Clinical infectious diseases 1995-05, Vol.20 (5), p.1195-1200
Main Authors: Moreno, Santiago, García-Leoni, Maria E., Cercenado, Emilia, Diaz, Maria D., de Quirós, Juan C. L. Bernaldo, Bouza, Emilio
Format: Article
Language:English
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Summary:To evaluate the incidence and the significance of resistance to erythromycin among clinical isolates of Streptococcus pneumoniae, we identified and prospectively followed all hospitalized patients in a 27-month period who had the organism isolated from any clinical sample. Patients who had an infection caused by pneumococci resistant to erythromycin (minimum inhibitory concentration, >1 µg/mL) were compared to those with infections caused by erythromycinsusceptible organisms. The incidence of erythromycin resistance among pneumococci doubled over the study period (from 7.6% in 1988 to 15.2% in 1992). Most strains (94%) showed resistance to multiple antibiotics, including other macrolides. By multivariate analysis, an age of
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/20.5.1195