Facilitation of calcium blocking and membrane effects by intrinsic sympathomimetic activity

The interactions between ICI 118, 587 (Corwin®) a β1-selective partial adrenergic agonist, and atenolol (Tenormin®), propranolol (Inderal®) and verapamil were examined first in anaesthetised dogs pretreated with syrosingopine and vagotomised. ICI 118,587 was administered iv in cumulative doses of 0....

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Bibliographic Details
Published in:Cardiovascular research 1984-01, Vol.18 (1), p.30-36
Main Authors: SMITH, HOWARD J, HALLIDAY, SHARON E, BRISCOE, MARTYN G, SNOW, H MICHAEL
Format: Article
Language:English
Subjects:
Adrenergic beta-Agonists - pharmacology
Animals
Antiarythmic agents
atenolol
Atenolol - pharmacology
Biological and medical sciences
Calcium - pharmacology
calcium antagonist
calcium entry blocker
Cardiovascular system
Depression, Chemical
Dogs
Dose-Response Relationship, Drug
Drug Interactions
Female
Heart Rate - drug effects
ICI 118
In Vitro Techniques
Medical sciences
membrane stabilising activity
Myocardial Contraction - drug effects
partial agonist
Pharmacology. Drug treatments
Propanolamines - pharmacology
propranolol
Propranolol - pharmacology
verapamil
Verapamil - pharmacology
Xamoterol
β-adrenoceptor antagonist
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Summary:The interactions between ICI 118, 587 (Corwin®) a β1-selective partial adrenergic agonist, and atenolol (Tenormin®), propranolol (Inderal®) and verapamil were examined first in anaesthetised dogs pretreated with syrosingopine and vagotomised. ICI 118,587 was administered iv in cumulative doses of 0.1 to 1000 μg·kg−1. In four animals, heart rate increased from 102±4 to 188±12 beats·min−1 with a KA of 2.5±0.9 μg·kg−l. ICI 118,587 was then administered to five groups each of four animals pretreated with atenolol (250 μg·kg−1 and 500 μg·kg−1iv), propranolol (250 μg·kg−1 and 500 μg·kg−1) or verapamil (200 μg·kg−l plus 5 μg·kg−1 min−1 iv). Both atenolol and propranolol shifted the dose response curve to the right but verapamil did not. Atenolol did not lower the maximal heart rate response to ICI 118,587. Both propanolol and verapamil slowed heart rate significantly (P
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/18.1.30