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Cardiac autonomic dysfunction and neuroganglionitis in a rat model of chronic Chaga's disease
Objective: The aim was to evaluate whether the cardiac parasympathetic function in a rat model of chronic Chagas' disease is impaired as in the human disease, and to correlate the functional state to histopathology of the intrinsic autonomic innervation of heart. Methods: 70 male Wistar rats 8...
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| Published in: | Cardiovascular research 1992-04, Vol.26 (4), p.324-329 |
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| container_end_page | 329 |
| container_issue | 4 |
| container_start_page | 324 |
| container_title | Cardiovascular research |
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| creator | Junqueira, Luiz F Beraldo, Paulo S S Chapadeiro, Edmundo Jesus, Paulo C |
| description | Objective: The aim was to evaluate whether the cardiac parasympathetic function in a rat model of chronic Chagas' disease is impaired as in the human disease, and to correlate the functional state to histopathology of the intrinsic autonomic innervation of heart. Methods: 70 male Wistar rats 8 months infected with strains Y (n=22), Sao Felipe (n=18), and Colombia (n=30) of Trypanosoma cruzi, were compared with 20 age and sex matched non-infected controls. Baroreflex bradycardia was quantified after multiple bolus injections of phenylephrine (3 to 12 μg). For each rat studied a mean was obtained of the absolute and relative (Δ%) ratio (index) between the maximum heart rate decrease and the maximum systolic blood pressure increase. Results: For the relative index the means were smaller (p |
| doi_str_mv | 10.1093/cvr/26.4.324 |
| format | article |
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Methods: 70 male Wistar rats 8 months infected with strains Y (n=22), Sao Felipe (n=18), and Colombia (n=30) of Trypanosoma cruzi, were compared with 20 age and sex matched non-infected controls. Baroreflex bradycardia was quantified after multiple bolus injections of phenylephrine (3 to 12 μg). For each rat studied a mean was obtained of the absolute and relative (Δ%) ratio (index) between the maximum heart rate decrease and the maximum systolic blood pressure increase. Results: For the relative index the means were smaller (p<0.05) in the Y [-0.52(SD 0.19)%], São Felipe [-0.45(0.28)%], and Colombia [-0.53(0.21%)] subgroups, as well as in the pooled chagasic group [-0.51(0.22)%], than in the control group [-0.64(0.13)%]. In 32% (7/22), 33%(6/18), and 20% (6/30) of rats infected with Y, Sao Felipe, and Colombia strains, respectively, and in 27% (19/70) of the pooled group rats, the index exceeded the control group mean by -2 SD. After atropinisation, a similar pronounced reduction (p<0.01) in the index was observed in all groups [-84(28)% to -95(17)%]; however, rats with depressed bradycardia showed a smaller (p<0.05) reduction in the relative index than control rats, at -70(34) v -92(16)%. Inflammatory and degenerative lesions of the intrinsic cardiac innervation were observed in 87% of the rats with autonomic dysfunction. Rats with the lesions showed a mean relative index that was smaller than diose without lesions, at -0.44(0.23) v -0.64(0.20)% (p<0.01), and also smaller than in the controls. Conclusions: Cardiac autonomic dysfunction expressed by reduced baroreflex bradycardia was detected in rats chronically infected with T cruzi, as in human Chagas' disease. The disturbance, shown for the first time in an animal model of chagasic infection, resulted primarily from impaired efferent parasympathetic activity caused by intrinsic neuroganglionar lesions.</description><identifier>ISSN: 0008-6363</identifier><identifier>EISSN: 1755-3245</identifier><identifier>DOI: 10.1093/cvr/26.4.324</identifier><identifier>PMID: 1638561</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Atropine - pharmacology ; baroreflex bradycardia ; Blood Pressure - drug effects ; Bradycardia - chemically induced ; cardiac parasympathetic dysfunction ; Chagas Disease - pathology ; Chagas Disease - physiopathology ; Disease Models, Animal ; Ganglia, Autonomic - pathology ; Ganglia, Autonomic - physiopathology ; Heart Rate - drug effects ; Male ; Myocardium - pathology ; neuroganglionitis ; Parasympathetic Nervous System - physiopathology ; Phenylephrine - pharmacology ; rat model of Chagas' disease ; Rats ; Rats, Inbred Strains ; T cruzi</subject><ispartof>Cardiovascular research, 1992-04, Vol.26 (4), p.324-329</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-c7751cccd1e2927b5a2487cbb238e179e56784c6e0107d32ca1ef8e4564458fd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1638561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Junqueira, Luiz F</creatorcontrib><creatorcontrib>Beraldo, Paulo S S</creatorcontrib><creatorcontrib>Chapadeiro, Edmundo</creatorcontrib><creatorcontrib>Jesus, Paulo C</creatorcontrib><title>Cardiac autonomic dysfunction and neuroganglionitis in a rat model of chronic Chaga's disease</title><title>Cardiovascular research</title><addtitle>Cardiovasc Res</addtitle><description>Objective: The aim was to evaluate whether the cardiac parasympathetic function in a rat model of chronic Chagas' disease is impaired as in the human disease, and to correlate the functional state to histopathology of the intrinsic autonomic innervation of heart. Methods: 70 male Wistar rats 8 months infected with strains Y (n=22), Sao Felipe (n=18), and Colombia (n=30) of Trypanosoma cruzi, were compared with 20 age and sex matched non-infected controls. Baroreflex bradycardia was quantified after multiple bolus injections of phenylephrine (3 to 12 μg). For each rat studied a mean was obtained of the absolute and relative (Δ%) ratio (index) between the maximum heart rate decrease and the maximum systolic blood pressure increase. Results: For the relative index the means were smaller (p<0.05) in the Y [-0.52(SD 0.19)%], São Felipe [-0.45(0.28)%], and Colombia [-0.53(0.21%)] subgroups, as well as in the pooled chagasic group [-0.51(0.22)%], than in the control group [-0.64(0.13)%]. In 32% (7/22), 33%(6/18), and 20% (6/30) of rats infected with Y, Sao Felipe, and Colombia strains, respectively, and in 27% (19/70) of the pooled group rats, the index exceeded the control group mean by -2 SD. After atropinisation, a similar pronounced reduction (p<0.01) in the index was observed in all groups [-84(28)% to -95(17)%]; however, rats with depressed bradycardia showed a smaller (p<0.05) reduction in the relative index than control rats, at -70(34) v -92(16)%. Inflammatory and degenerative lesions of the intrinsic cardiac innervation were observed in 87% of the rats with autonomic dysfunction. Rats with the lesions showed a mean relative index that was smaller than diose without lesions, at -0.44(0.23) v -0.64(0.20)% (p<0.01), and also smaller than in the controls. Conclusions: Cardiac autonomic dysfunction expressed by reduced baroreflex bradycardia was detected in rats chronically infected with T cruzi, as in human Chagas' disease. The disturbance, shown for the first time in an animal model of chagasic infection, resulted primarily from impaired efferent parasympathetic activity caused by intrinsic neuroganglionar lesions.</description><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>baroreflex bradycardia</subject><subject>Blood Pressure - drug effects</subject><subject>Bradycardia - chemically induced</subject><subject>cardiac parasympathetic dysfunction</subject><subject>Chagas Disease - pathology</subject><subject>Chagas Disease - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Ganglia, Autonomic - pathology</subject><subject>Ganglia, Autonomic - physiopathology</subject><subject>Heart Rate - drug effects</subject><subject>Male</subject><subject>Myocardium - pathology</subject><subject>neuroganglionitis</subject><subject>Parasympathetic Nervous System - physiopathology</subject><subject>Phenylephrine - pharmacology</subject><subject>rat model of Chagas' disease</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>T cruzi</subject><issn>0008-6363</issn><issn>1755-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNpFkM9LwzAYhoMoc05vXoXcvNgtv9MepagTBl6UiSAhTdIturaStOL-eyMVPX3f9z4v3-EB4ByjOUYFXZjPsCBizuaUsAMwxZLzLK38EEwRQnkmqKDH4CTGt3RyLtkETLCgORd4Cl5LHazXBuqh79qu8QbafayH1vS-a6FuLWzdELqNbje7lPjeR-gTgEH3sOms28GuhmYbEjOw3OqNvozQ-uh0dKfgqNa76M5-5ww83d48lsts9XB3X16vMkML1mdGSo6NMRY7UhBZcU1YLk1VEZo7LAvHhcyZEQ5hJC0lRmNX545xwRjPa0tn4Gr8a0IXY3C1-gi-0WGvMFI_klSSpIhQTCUzqX4x1j-GqnH2vzxaSTwbuY-9-_rDOrwrIankavn8ohgvKV-vl6qk3y_qcog</recordid><startdate>19920401</startdate><enddate>19920401</enddate><creator>Junqueira, Luiz F</creator><creator>Beraldo, Paulo S S</creator><creator>Chapadeiro, Edmundo</creator><creator>Jesus, Paulo C</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19920401</creationdate><title>Cardiac autonomic dysfunction and neuroganglionitis in a rat model of chronic Chaga's disease</title><author>Junqueira, Luiz F ; Beraldo, Paulo S S ; Chapadeiro, Edmundo ; Jesus, Paulo C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-c7751cccd1e2927b5a2487cbb238e179e56784c6e0107d32ca1ef8e4564458fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>baroreflex bradycardia</topic><topic>Blood Pressure - drug effects</topic><topic>Bradycardia - chemically induced</topic><topic>cardiac parasympathetic dysfunction</topic><topic>Chagas Disease - pathology</topic><topic>Chagas Disease - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Ganglia, Autonomic - pathology</topic><topic>Ganglia, Autonomic - physiopathology</topic><topic>Heart Rate - drug effects</topic><topic>Male</topic><topic>Myocardium - pathology</topic><topic>neuroganglionitis</topic><topic>Parasympathetic Nervous System - physiopathology</topic><topic>Phenylephrine - pharmacology</topic><topic>rat model of Chagas' disease</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>T cruzi</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Junqueira, Luiz F</creatorcontrib><creatorcontrib>Beraldo, Paulo S S</creatorcontrib><creatorcontrib>Chapadeiro, Edmundo</creatorcontrib><creatorcontrib>Jesus, Paulo C</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Cardiovascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Junqueira, Luiz F</au><au>Beraldo, Paulo S S</au><au>Chapadeiro, Edmundo</au><au>Jesus, Paulo C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac autonomic dysfunction and neuroganglionitis in a rat model of chronic Chaga's disease</atitle><jtitle>Cardiovascular research</jtitle><addtitle>Cardiovasc Res</addtitle><date>1992-04-01</date><risdate>1992</risdate><volume>26</volume><issue>4</issue><spage>324</spage><epage>329</epage><pages>324-329</pages><issn>0008-6363</issn><eissn>1755-3245</eissn><abstract>Objective: The aim was to evaluate whether the cardiac parasympathetic function in a rat model of chronic Chagas' disease is impaired as in the human disease, and to correlate the functional state to histopathology of the intrinsic autonomic innervation of heart. Methods: 70 male Wistar rats 8 months infected with strains Y (n=22), Sao Felipe (n=18), and Colombia (n=30) of Trypanosoma cruzi, were compared with 20 age and sex matched non-infected controls. Baroreflex bradycardia was quantified after multiple bolus injections of phenylephrine (3 to 12 μg). For each rat studied a mean was obtained of the absolute and relative (Δ%) ratio (index) between the maximum heart rate decrease and the maximum systolic blood pressure increase. Results: For the relative index the means were smaller (p<0.05) in the Y [-0.52(SD 0.19)%], São Felipe [-0.45(0.28)%], and Colombia [-0.53(0.21%)] subgroups, as well as in the pooled chagasic group [-0.51(0.22)%], than in the control group [-0.64(0.13)%]. In 32% (7/22), 33%(6/18), and 20% (6/30) of rats infected with Y, Sao Felipe, and Colombia strains, respectively, and in 27% (19/70) of the pooled group rats, the index exceeded the control group mean by -2 SD. After atropinisation, a similar pronounced reduction (p<0.01) in the index was observed in all groups [-84(28)% to -95(17)%]; however, rats with depressed bradycardia showed a smaller (p<0.05) reduction in the relative index than control rats, at -70(34) v -92(16)%. Inflammatory and degenerative lesions of the intrinsic cardiac innervation were observed in 87% of the rats with autonomic dysfunction. Rats with the lesions showed a mean relative index that was smaller than diose without lesions, at -0.44(0.23) v -0.64(0.20)% (p<0.01), and also smaller than in the controls. Conclusions: Cardiac autonomic dysfunction expressed by reduced baroreflex bradycardia was detected in rats chronically infected with T cruzi, as in human Chagas' disease. The disturbance, shown for the first time in an animal model of chagasic infection, resulted primarily from impaired efferent parasympathetic activity caused by intrinsic neuroganglionar lesions.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>1638561</pmid><doi>10.1093/cvr/26.4.324</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cardiovascular research, 1992-04, Vol.26 (4), p.324-329 |
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| language | eng |
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| source | Oxford University Press Archive |
| subjects | Animals Atropine - pharmacology baroreflex bradycardia Blood Pressure - drug effects Bradycardia - chemically induced cardiac parasympathetic dysfunction Chagas Disease - pathology Chagas Disease - physiopathology Disease Models, Animal Ganglia, Autonomic - pathology Ganglia, Autonomic - physiopathology Heart Rate - drug effects Male Myocardium - pathology neuroganglionitis Parasympathetic Nervous System - physiopathology Phenylephrine - pharmacology rat model of Chagas' disease Rats Rats, Inbred Strains T cruzi |
| title | Cardiac autonomic dysfunction and neuroganglionitis in a rat model of chronic Chaga's disease |
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