Cardiovascular function and survival during severe systemic hypoxaemia : influence of glucosepotassium-insulin solution and of beta-blockade

Anaesthetized dogs were ventilated with 3·6% O2 after having been given infusions of isotonic saline or glucose-potassium-insulin (GKI) solution. Initial tachycardia and hypertension were superseded by progressive circulatory failure and death in all dogs. In the absence of beta-adrenergic blockade,...

Full description

Saved in:
Bibliographic Details
Published in:Cardiovascular research 1973-03, Vol.7 (2), p.174-180
Main Authors: WILDENTHAL, KERN, CRIE, J. STANLEY, VASTAGH, GEORGE F.
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anaesthetized dogs were ventilated with 3·6% O2 after having been given infusions of isotonic saline or glucose-potassium-insulin (GKI) solution. Initial tachycardia and hypertension were superseded by progressive circulatory failure and death in all dogs. In the absence of beta-adrenergic blockade, no significant differences in haemodynamic responses or survival times occurred in the animals that received the two solutions. Propranolol, itself, increased the survival time in both groups. In addition, after pretreatment with propranolol, which prevented a rise in blood glucose after the onset of hypoxia, dogs that received GKI survived significantly longer than those with persistently low blood glucose levels.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/7.2.174