494. DO WE NEED GENDER SPECIFIC GUIDELINES FOR ESOPHAGEAL CANCER MANAGEMENT?

Abstract Background The incidence of esophageal cancer is disproportionately greater in males, but trials of treatments are not gender stratified. It is unclear whether the response or outcome following neoadjuvant chemoradiotherapy (NCR) is gender specific. This study compared the presentation, res...

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Bibliographic Details
Published in:Diseases of the esophagus 2024-09, Vol.37 (Supplement_1)
Main Authors: Abdulrahman, Maan, Abdulrahman, Rand, Viani-Walsh, Dylan, Hashem, Jamal, Grogan, Liam, O'Niell, Brian, Kumar, Nitya, Sorensen, Jan, Walsh, Thomas Noel
Format: Article
Language:English
Online Access:Get full text
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Summary:Abstract Background The incidence of esophageal cancer is disproportionately greater in males, but trials of treatments are not gender stratified. It is unclear whether the response or outcome following neoadjuvant chemoradiotherapy (NCR) is gender specific. This study compared the presentation, response to NCR and outcome of female with male patients. (48) Methods A prospectively maintained database of 205 esophageal carcinoma patients treated with curative intent between 1998 and 2019 was interrogated for the impact of gender on presentation, response to NCR treatment and survival. (32 words) Results Of 205 patients, 59 (29%) females were significantly older than males [mean (SD) age 66.1 (10.8) v. 61.6 (11.2) (p=0.008)]. Sixty-six percent of females had squamous cell carcinoma (SCC) while 116 (79.5%) males had adenocarcinoma (AC) (
ISSN:1120-8694
1442-2050
DOI:10.1093/dote/doae057.231