P193 Fatigued patients with Inflammatory Bowel Disease exhibit distinct systemic antibody epitope repertoires

Abstract Background Patients with inflammatory bowel diseases (IBD) frequently experience fatigue, affecting up to 80% of those with active disease and approximately 50% with quiescent disease. The exact cause of IBD-associated fatigue is often unknown, making clinical management very challenging. I...

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Published in:Journal of Crohn's and colitis 2024-01, Vol.18 (Supplement_1), p.i507-i508
Main Authors: Griesbaum, M G, Vogl, T, Andreu-Sánchez, S, Klompus, S, Kalka, I N, Leviatan, S, van Dullemen, H M, Visschedijk, M C, Festen, E A M, Faber, K N, Dijkstra, G, Weinberger, A, Segal, E, Weersma, R K, Bourgonje, A R
Format: Article
Language:English
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Summary:Abstract Background Patients with inflammatory bowel diseases (IBD) frequently experience fatigue, affecting up to 80% of those with active disease and approximately 50% with quiescent disease. The exact cause of IBD-associated fatigue is often unknown, making clinical management very challenging. In this study we aimed to explore whether patients with quiescent IBD reporting fatigue exhibit specific systemic antibody responses, which could provide insight into immune reactivities underlying fatigue. Methods Systemic antibody epitope repertoires were profiled in 327 patients with IBD (156 Crohn’s disease [CD]; 171 ulcerative colitis [UC]) leveraging phage-display immunoprecipitation sequencing (PhIP-Seq) against 344,000 rationally selected peptide antigens. Fatigue severity was assessed on a 10-point Likert scale, ranging from 1 (no fatigue) to 10 (highest fatigue severity). Quiescent IBD was defined as clinical (Harvey-Bradshaw Index [HBI]
ISSN:1873-9946
1876-4479
DOI:10.1093/ecco-jcc/jjad212.0323