P231 CRP/Albumin ratio associated with disease activity in ulcerative colitis

• Published in: Journal of Crohn's and colitis 2018-01, Vol.12 (supplement_1), p.S217-S217
• Main Authors: Sayar, S, Kahraman, R, Kürbüz, K, Atalay, R, Ozturk, O, Doganay, H L, Calışkan, Z, Ozdil, K
• Format: Article
• Language: English
• ISSN: 1873-9946; 1876-4479
• DOI: 10.1093/ecco-jcc/jjx180.358

Abstract Background There are several indices and markers of inflammation used to determine disease activity in ulcerative colitis. CRP levels have limited efficiency to show disease activity. Low albumin levels are associated with unresponsiveness to treatment and severe disease activity. In this study we aim to show if there is a correlation of CRP/Albumin ratio (CAR) with disease activity. Methods Hospital records of patients with ulcerative colitis were screened through the time frame of November 2011 and February 2017. 149 patients were included in the study. Patients’ demographic data, laboratory values, clinical disease activity, endoscopic activity scores, and their treatment were evaluated. Results 99 (%62) male and 50 (%38) female patients were included in the study. Mean age was 45.22 ± 14 years. When patients were grouped into remission, mild, moderate and severe disease according to disease activity, there were statistically significant difference between CRP, CAR, erythrocyte sedimentation rate (ESR) and albumin levels (p = 0.001; p < 0.05). Are under ROC (AUROC) values for the diagnosis of severe disease were 0.941, 0.931, 0.888 and 0.883 for CAR, CRP, ESR and albumin levels, respectively. Cut-off value to determine severe disease for CAR was 0.6 (sensitivity: 88.9%, specificity of 90.3%, positive predictive value (PPV) 85.1%, negative predictive value (NPV) 92.8%, AUROC: 0.941, p < 0.001). Conclusions There were significant relationship between CAR, CRP, ESR and albumin levels and disease severity in patients with ulcerative colitis. CAR has higher positive predictive value and specificity than CRP, ESR and albumin levels to determine severe clinical activity.