Long-term Outcomes of Paediatric Patients Admitted With Acute Severe Colitis— A Multicentre Study From the Paediatric IBD Porto Group of ESPGHAN

• Published in: Journal of Crohn's and colitis 2019-12, Vol.13 (12), p.1518-1526
• Main Authors: Krauthammer, Alex, Tzivinikos, Christos, Assa, Amit, Miele, Erasmo, Strisciuglio, Caterina, Urlep, Darja, Serban, Elena Daniela, Singh, Avantika, Winter, Harland S, Russell, Richard K, Hojsak, Iva, Malham, Mikkel, Navas-López, Víctor Manuel, Croft, Nicholas M, Lee, Huey Miin, Ledder, Oren, Shamasneh, Ibrahim, Hussey, Seamus, Huynh, Hien Q, Wine, Eytan, Shah, Neil, Sladek, Margaret, de Meij, Tim G, Romano, Claudio, Dipasquale, Valeria, Lionetti, Paolo, Afzal, Nadeem A, Aloi, Marina, Lee, Kwangyang, Martín-de-Carpi, Javier, Yerushalmy-Feler, Anat, Subramanian, Sreedhar, Weiss, Batia, Shouval, Dror S
• Format: Article
• Language: English
• Subjects: Child; Colectomy - adverse effects; Colectomy - methods; Colectomy - statistics & numerical data; Colitis, Ulcerative - diagnosis; Colitis, Ulcerative - therapy; Europe - epidemiology; Female; Glucocorticoids - therapeutic use; Humans; Infliximab - therapeutic use; Long Term Adverse Effects - epidemiology; Male; North America - epidemiology; Outcome and Process Assessment, Health Care; Retrospective Studies; Severity of Illness Index; Tumor Necrosis Factor Inhibitors - therapeutic use
• ISSN: 1873-9946; 1876-4479
• DOI: 10.1093/ecco-jcc/jjz092

Abstract Background and Aim Acute severe colitis [ASC] is associated with significant morbidity in paediatric patients with ulcerative colitis [UC]. Most outcome studies in ASC since tumour necrosis factor alpha [TNFα] antagonists became available have focused on the first year after admission. The aim of this study was to characterise the longer-term outcomes of paediatric patients admitted with ASC. Methods This retrospective study was conducted in 25 centres across Europe and North America. Data on patients with UC aged 70 mm/h, and albumin