P340 New tools for the assesment of diastolic function in attr cardiac amyloidosis

• Published in: European heart journal cardiovascular imaging 2020-01, Vol.21 (Supplement_1)
• Main Authors: Gonzalez Ferrero, T, Abou Jokh Casas, C A J C, Cacho Antonio, C C A, Abou Jokh Casas, E A J C, Antunez Muinos, P A M, Perez Dominguez, M P D, Torrelles Fortuny, A T F, Pubul Nunez, V P N, Martinez Monzonis, A M M, Gonzalez Juanatey, J R G J
• Format: Article
• Language: English
• ISSN: 2047-2404; 2047-2412
• DOI: 10.1093/ehjci/jez319.193

Abstract INTRODUCCION Cardiac amyloidosis (CA) is a cardiomyopathy where the main disturbances are due to diastolic dysfunction. This requires a meticulous clinical and echocardiograpic evaluation. METHODS The aim of this study was to analyse the association between previously described parameters of diastolic dysfunction and others less known such as left atrial peak strain. RESULTS Thirty-six patients with suspicion of cardiac amyloidosis were submitted to DPD scintigraphyand transthoracic echocardiography, and were divided into two groups. Of these patients, eleven had no visual gammagraphic catchment whereas twenty-four, (68%) did. Median peak of atrial strain was 16.8 in sinus rhythm and 6.8% in atrial fibrillation (p  14) was systolic strain left atrial peak (p = 0,004 IC 95% 0.8-0.9) with an accurate predictive ability, AUC (76%). CONCLUSIONS Left atrial strain peak could be an interesting parameter for the assessment of diastolic dysfunction and a protective value for elevated filling pressures in CA-ATTR patients. Basal features ABSENCE OF CATCHMENT POSITIVE CATCHMENT P-value E (m/s) 0.77 1.17 0.04 A (m/s) 0.76 0.9 0.64 E/A 195 181 0.91 E/e’ 14 0.9 0.73 Atrial strain peak 8.5 11.8 0.78 35% AF 45% AF Fractional shortening (%) 34.34 31.80 0.81 Differences between both groups Abstract P340 Figure. Relationship: E/e" and atrial strain