NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1256 patients

Aims Experience with amino-terminal pro-brain natriuretic peptide (NT-proBNP) testing for evaluation of dyspnoeic patients with suspected acute heart failure (HF) is limited to single-centre studies. We wished to establish broader standards for NT-proBNP testing in a study involving four sites in th...

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Bibliographic Details
Published in:European heart journal 2006-02, Vol.27 (3), p.330-337
Main Authors: Januzzi, James L., van Kimmenade, Roland, Lainchbury, John, Bayes-Genis, Antoni, Ordonez-Llanos, Jordi, Santalo-Bel, Miguel, Pinto, Yigal M., Richards, Mark
Format: Article
Language:English
Subjects:
Diagnosis
Natriuretic peptides
Prognosis
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Summary:Aims Experience with amino-terminal pro-brain natriuretic peptide (NT-proBNP) testing for evaluation of dyspnoeic patients with suspected acute heart failure (HF) is limited to single-centre studies. We wished to establish broader standards for NT-proBNP testing in a study involving four sites in three continents. Methods and results Differences in NT-proBNP levels among 1256 patients with and without acute HF and the relationship between NT-proBNP levels and HF symptoms were examined. Optimal cut-points for diagnosis and prognosis were identified and verified using bootstrapping and multi-variable logistic regression techniques. Seven hundred and twenty subjects (57.3%) had acute HF, whose median NT-proBNP was considerably higher than those without (4639 vs. 108 pg/mL, P5180 pg/mL was strongly predictive of death by 76 days [odds ratio=5.2, 95% confidence interval (CI)=2.2–8.1, P
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehi631