P3423The contribution of genetics to premature CAD through different degrees of lifestyle factors: a matter of relative significance?

• Published in: European heart journal 2019-10, Vol.40 (Supplement_1)
• Main Authors: Sousa, J, Mendonca, M, Pereira, A, Mendonca, F, Neto, M, Monteiro, J, Sousa, A C, Rodrigues, M, Henriques, E, Guerra, G, Borges, S, Ornelas, I, Drumond, A, Palma Dos Reis, R
• Format: Article
• Language: English
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/eurheartj/ehz745.0297

Abstract Introduction Coronary artery disease (CAD) is a multifactorial process with substantial genetic contribution. However, genetic predisposition among patients with a different number of lifestyle factors and premature CAD, remains a complex and thoroughly unexplored topic. Objective To evaluate, in a young population, the importance of conventional risk factors as well as of a genetic risk score in the appearance of CAD. Methods A case-control study was conducted with 1075 patients from the GENEMACOR study population, under 50 years-old (555 cases, 86.8% male, mean age 44.1±4.9 years and 520 controls, 86.2% male, mean age 44.3±4.8 years). Univariate analysis addressed the association of different modifiable risk factors with premature CAD. Genetic risk score (GRS) was computed comprising 33 genetic risk variants in a multiplicative method. GRS was evaluated according to the number of traditional risk factors and risk for premature CAD was estimated and its independent predictive value estimated by logistic regression. Results 72.6% of patients had ≥3 risk factors vs 31.2% of controls (p