P4392A systematic review and meta-analysis of the cardiovascular effects of e-cigarette

Abstract Background Electronic cigarette (EC) is marketed as a safe alternative to tobacco smoking, but EC cardiovascular effects remains largely unknown. Purpose To systematically review and meta-analyse published literature to investigate the cardiovascular effects and associated risk from EC use....

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Bibliographic Details
Published in:European heart journal 2019-10, Vol.40 (Supplement_1)
Main Authors: Antonopoulos, A S, Skotsimara, G, Oikonomou, E, Ioakeimidis, N, Mistakidi, C V, Georgakopoulos, C, Galiatsatos, N, Charalampous, G, Vlachopoulos, C, Tousoulis, D
Format: Article
Language:English
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Summary:Abstract Background Electronic cigarette (EC) is marketed as a safe alternative to tobacco smoking, but EC cardiovascular effects remains largely unknown. Purpose To systematically review and meta-analyse published literature to investigate the cardiovascular effects and associated risk from EC use. Methods We searched PubMed from January 2000 until November 2017 for published studies assessing the cardiovascular effects of EC. For each eligible study we used the mean difference (MD) with 95% confidence intervals (CIs) for SBP, DBP and HR. The pooled MDs for each outcome of interest were calculated by using a fixed effects model. The presence of heterogeneity among studies was evaluated by the I2 statistic. Results We report conflicting evidence on the effects of EC on heart rate and blood pressure, which is mainly based on non-randomized clinical studies of moderate quality. In a meta-analysis of 14 studies (n=441 participants), that despite the negative effects of EC on heart rate (pooled MD=2.27, 95% CI: 1.64 to 2.89, p
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehz745.0797