2140Association of arterial stiffness with left atrial structure and phasic function: a community-based cohort study

• Published in: European heart journal 2019-10, Vol.40 (Supplement_1)
• Main Authors: Yoshida, Y, Nakanishi, K, Daimon, M, Ishiwata, J, Sawada, N, Hirokawa, M, Kaneko, H, Nakao, T, Mizuno, Y, Morita, H, Di Tullio, M R, Yatomi, Y, Homma, S, Komuro, I
• Format: Article
• Language: English
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/eurheartj/ehz748.0087

Abstract Background Increased arterial stiffness is recognized as an independent risk factor for atrial fibrillation, although the pathophysiological mechanisms remain unclear. Cardio-ankle vascular index (CAVI) is emerging as an important tool to assess arterial stiffness noninvasively which is derived from the concept of stiffness β index and is less dependent on blood pressure at the time of measurement than pulse wave velocity. Purpose This study aimed to investigate the association of arterial stiffness with left atrial (LA) volume and phasic function in a community-based cohort. Methods We included 1,156 participants without overt cardiovascular disease who underwent extensive cardiovascular examination. Arterial stiffness was evaluated by CAVI. Speckle-tracking echocardiography was employed to evaluate LA phasic function including reservoir, conduit and pump strain as well as left ventricular global longitudinal strain (LVGLS). Results CAVI was negatively correlated with reservoir and conduit strain (r=−0.37 and −0.45, both p