Leukocytosis in response to exogenous gonadotrophin stimulation

Leukocytosis may develop in women undergoing ovulation induction. The production of blood leukocytes and their numbers in circulation are regulated by complex interactions involving endogenous haematopoietic cytokines, such as granulocyte-colony stimulating factor (G-CSF), monocyte-colony stimulatin...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1997-10, Vol.12 (10), p.2143-2146
Main Authors: Hock, D L, Huhn, R D, Kemmann, E
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Female
Granulocyte Colony-Stimulating Factor - blood
Hematologic and hematopoietic diseases
Humans
Interleukin-6 - blood
Leukocyte Count
Leukocytosis - chemically induced
Luteal Phase
Macrophage Colony-Stimulating Factor - blood
Medical sciences
Menotropins - adverse effects
Menotropins - therapeutic use
Other diseases. Hematologic involvement in other diseases
Ovulation Induction - adverse effects
Prospective Studies
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Summary:Leukocytosis may develop in women undergoing ovulation induction. The production of blood leukocytes and their numbers in circulation are regulated by complex interactions involving endogenous haematopoietic cytokines, such as granulocyte-colony stimulating factor (G-CSF), monocyte-colony stimulating factor (M-CSF), and interleukins. The purpose of this prospective study was to explore the presence of leukocytosis in women who receive urinary menotrophins, and to determine whether haematopoietic cytokines are changed in the stimulation process. Controls were volunteers of the same age range, not taking any medication, who received daily saline injections. Subjects underwent phlebotomy at defined points for determination of complete blood counts, G-CSF, M-CSF, and interleukin-6 concentrations. Baseline white blood cell (WBC) counts were similar in patients and controls. In menotrophin-treated patients the WBC counts rose significantly (4.19 +/- 0.28 to 6.37 +/- 0.71) during the stimulation and peaked in the luteal phase (P = 0.037). In contrast, WBC counts decreased in controls. Other leukocytic lineages were not affected. In treated patients G-CSF concentrations rose significantly (P = 0.028 versus controls), while changes in M-CSF and interleukin-6 were not significant.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/12.10.2143