Effect of the Yuzpe regimen of emergency contraception on markers of endometrial receptivity

This exploratory study was designed to determine whether treatment with the Yuzpe regimen of emergency contraception altered endometrial integrin expression or other markers of uterine receptivity. Nineteen parous women were followed for two menstrual cycles. In the second cycle, each participant to...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2000-11, Vol.15 (11), p.2351-2355
Main Authors: Raymond, Elizabeth G., Lovely, Laurie P., Chen-Mok, Mario, Seppälä, Markku, Kurman, Robert J., Lessey, Bruce A.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsy
Birth control
Contraception - adverse effects
Contraception - methods
Contraceptives, Postcoital - adverse effects
Contraceptives, Postcoital - pharmacology
emergency contraception
endometrial receptivity
Endometrium - diagnostic imaging
Endometrium - drug effects
Endometrium - pathology
Endometrium - physiology
Female
Gynecology. Andrology. Obstetrics
Hormonal contraception
Humans
integrins
leukaemia inhibitory factor
Medical sciences
oestrogen receptors
Ultrasonography
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Summary:This exploratory study was designed to determine whether treatment with the Yuzpe regimen of emergency contraception altered endometrial integrin expression or other markers of uterine receptivity. Nineteen parous women were followed for two menstrual cycles. In the second cycle, each participant took 100 mg ethinyl oestradiol and 1 mg norgestrel on the day of the urinary luteinizing hormone (LH) surge and repeated the dose 12 h later. In both cycles, endometrial biopsy, phlebotomy and vaginal sonogram were performed 8–10 days after the urinary LH surge. No significant difference was found between untreated and treated cycles in most measures of endometrial histology or in endometrial expression of β3 integrin subunit, leukaemia inhibitory factor, glycodelin, or progesterone receptors assessed by immunohistochemical techniques. Five statistically significant changes were noted in treated cycles: a reduction in endometrial MUC-1 expression, an increase in endometrial oestrogen receptor, lower luteal phase serum oestrogen concentration, reduced endometrial thickness, and greater proportion of glandular supranuclear vacuoles. The relationship of these findings to the contraceptive action of the Yuzpe regimen is unclear.
ISSN:0268-1161
1460-2350
1460-2350
DOI:10.1093/humrep/15.11.2351