204Effects of adiposity on the human proteome: Mendelian randomization study using individual-level data

Background Variation in body mass index (BMI) is associated with cardiometabolic health outcomes such as diabetes, but the mechanism(s) leading from BMI to disease remain unclear. This study used proteomic data measured by SomaLogic from healthy adults from the INTERVAL study to explore the effect o...

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Bibliographic Details
Published in:International journal of epidemiology 2021-09, Vol.50 (Supplement_1)
Main Authors: Goudswaard, Lucy, Bell, Joshua, Hughes, David, Walter, Klaudia, Soranzo, Nicole, Butterworth, Adam, Hers, Ingeborg, Timpson, Nicholas
Format: Article
Language:English
Online Access:Get full text
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Summary:Background Variation in body mass index (BMI) is associated with cardiometabolic health outcomes such as diabetes, but the mechanism(s) leading from BMI to disease remain unclear. This study used proteomic data measured by SomaLogic from healthy adults from the INTERVAL study to explore the effect of BMI on 3,622 unique plasma proteins using observational and genetically informed methods. Methods Linear regression models were used, complemented by one-sample Mendelian randomization (MR) analyses. A BMI genetic risk score (GRS) comprised of 654 SNPs from a recent genome-wide association study (GWAS) of adult BMI was used in both observational and MR analysis. Results Observationally, BMI was associated with 1,576 proteins at p
ISSN:0300-5771
1464-3685
DOI:10.1093/ije/dyab168.235