Persistent Urinary Tract Infection in Children: Treatment with Amoxicillin

• Published in: The Journal of infectious diseases 1974-06, Vol.129 (Supplement-2), p.S243-S245
• Main Authors: Mongeau, Jean-Guy, Mahfoud, Georges
• Format: Article
• Language: English
• Subjects: Administration, Oral; Adolescent; Amines - administration & dosage; Amines - adverse effects; Amines - therapeutic use; Child; Child health services; Child, Preschool; Cystitis - complications; Diarrhea - chemically induced; Escherichia coli - isolation & purification; Escherichia coli Infections - drug therapy; Female; Humans; Infant; Infections; Kidney Diseases - complications; Male; Pediatrics; Penicillin Resistance; Penicillins - administration & dosage; Penicillins - adverse effects; Penicillins - therapeutic use; Pseudomonas - isolation & purification; Pseudomonas Infections - drug therapy; Recurrence; Session VII. Treatment of Urinary Tract Infections; Side effects; Urethral stricture; Urethral Stricture - complications; Urinary tract; Urinary tract infections; Urinary Tract Infections - drug therapy; Urinary Tract Infections - etiology; Urine; Urine - microbiology; Vesico ureteral reflux; Vesico-Ureteral Reflux - complications
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/129.Supplement_2.S243

Amoxicillin was used in treatment of 20 children suffering from recurrent urinary tract infection. Patients were divided into three groups: those without obstruction, those with obstruction, and those with renal parenchymal damage. Amoxicillin eradicated organisms from over 80% of urine samples within 48 hr. Three weeks after onset of therapy, most of the patients were again infected either with the same organism (which had become resistant to therapy) or with a new organism. Amoxicillin was well tolerated by the children; diarrhea, the only side effect of the drug, was observed in two instances.