Use of Paramecia for Studying Toxic Substances in Urine

The results of these experiments indicate that urine from scarlet fever patients in the acute stage generally contains a toxic substance which kills paramecia and that this action is neutralized by scarlet fever antitoxin, but not by diphtheria antitoxin. A toxic substance is rarely found in the uri...

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Bibliographic Details
Published in:The Journal of infectious diseases 1929-09, Vol.45 (3), p.244-246
Main Author: Tunnicliff, Ruth
Format: Article
Language:English
Subjects:
Antitoxins
Diphtheria
Horses
Measles
Paramecia
Scarlet fever
Specimens
Toxicity
Toxins
Urine
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Summary:The results of these experiments indicate that urine from scarlet fever patients in the acute stage generally contains a toxic substance which kills paramecia and that this action is neutralized by scarlet fever antitoxin, but not by diphtheria antitoxin. A toxic substance is rarely found in the urine of patients after the administration of scarlet fever antitoxin and does not appear to be present during convalescence. A substance toxic for paramecia which could be neutralized by scarlet fever antitoxin, anti-measles-diplococcus goat serum, normal goat serum or by convalescent human measles serum.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/45.3.244