A Pneumotropic Pasteurella of Laboratory Animals. I. Bacteriological and Serological Characteristics of the Organism

1. In the course of rapid serial passage of mouse lung, pneumonic lesions were encountered. A pasteurella-like organism was regularly recovered from the lesions and shown to be responsible for the disease process. 2. Bacteriological and serological studies indicated that the pasteurella was not iden...

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Bibliographic Details
Published in:The Journal of infectious diseases 1950-03, Vol.86 (2), p.172-183
Main Author: Jawetz, Ernest
Format: Article
Language:English
Subjects:
Animal diseases
Animals
Antigens
Breeding
Inoculation
Laboratory animals
Lesions
Lungs
Mice
Pasteurella
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Summary:1. In the course of rapid serial passage of mouse lung, pneumonic lesions were encountered. A pasteurella-like organism was regularly recovered from the lesions and shown to be responsible for the disease process. 2. Bacteriological and serological studies indicated that the pasteurella was not identical with any known species. Its outstanding characteristic was its striking pneumotropism in mice, producing no lesions in any organ except the lung after inoculation by any route. Therefore the name of Pasteurella pneumotropica is proposed for this bacterium. 3. Mice from a number of mouse colonies in the eastern United States were shown to carry the organism latently in their respiratory tract. No spontaneous epizootics have been noticed in these colonies for several years. Pathogenicity of latent P. pneumotropica appears to be a function of intranasal passage of mouse lung material. The organism was also recovered from the respiratory tract of other small laboratory animals, but no lesions could be induced in them. 4. It is suggested that P. pneumotropica is related to other Pasteurella species found in mice and that its peculiar characteristics may have evolved in the course of adaptive changes in hose and parasite.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/86.2.172