Monkeypox Virus Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to Modified Vaccinia Virus Ankara Vaccination

Monkeypox virus (MPXV) has recently caused a global disease outbreak in humans. Differences in the neutralizing antibody response to vaccination versus MPXV infection remain poorly understood. Here, we examined the neutralization of MPXV and vaccinia virus by sera from a cohort of convalescent and v...

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Published in:The Journal of infectious diseases 2024-11
Main Authors: Selverian, Christopher N, Monticelli, Stephanie R, Jaleta, Yakin M, Lasso, Gorka, DeMouth, Megan E, Meola, Annalisa, Berrigan, Jacob, Batchelor, Thomas G, Battini, Leandro, Guardado-Calvo, Pablo, Herbert, Andrew S, Chandran, Kartik, Meyerowitz, Eric, Miller, Emily Happy
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container_title The Journal of infectious diseases
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creator Selverian, Christopher N
Monticelli, Stephanie R
Jaleta, Yakin M
Lasso, Gorka
DeMouth, Megan E
Meola, Annalisa
Berrigan, Jacob
Batchelor, Thomas G
Battini, Leandro
Guardado-Calvo, Pablo
Herbert, Andrew S
Chandran, Kartik
Meyerowitz, Eric
Miller, Emily Happy
description Monkeypox virus (MPXV) has recently caused a global disease outbreak in humans. Differences in the neutralizing antibody response to vaccination versus MPXV infection remain poorly understood. Here, we examined the neutralization of MPXV and vaccinia virus by sera from a cohort of convalescent and vaccinated individuals at 1 and 8 months postexposure. Convalescent individuals displayed higher neutralizing antibody titers against MPXV than vaccinated and MPXV-naive persons at 1 month postexposure. Neutralizing antibody titers had waned significantly in both groups at 8 months. This study suggests that additional vaccine strategies are needed to elicit a durable humoral response and prevent breakthrough infections.
doi_str_mv 10.1093/infdis/jiae515
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title Monkeypox Virus Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to Modified Vaccinia Virus Ankara Vaccination
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