Comparative study of ceftizoxime and cefamandole in the treatment of bronchopulmonary infections

A prospective, randomized, single-blind comparison of ceftizoxime and cefamandole was conducted in 53 adult patients hospitalized with pneumonia or purulent tracheobronchitis. Twenty-nine of 31 patients treated with ceftizoxime and 15 of 16 patients treated with cefamandole achieved clinical cure. B...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1982-01, Vol.10 (suppl-C), p.215-221
Main Authors: LeFrock, Jack L., Molavi, Abdolghader, Lentnek, Arnold L., Rolston, Kenneth V. I., Chandrasekar, Pranatharthi H., Smith, Bruce R., Kannangara, Walter, Schell, Ronald F., Oaks, Susan S., Carr, Bernice B.
Format: Article
Language:English
Subjects:
Adult
Aged
Bronchitis - drug therapy
Bronchitis - microbiology
Cefamandole - adverse effects
Cefamandole - therapeutic use
Cefotaxime - adverse effects
Cefotaxime - analogs & derivatives
Cefotaxime - therapeutic use
Ceftizoxime
Cephalosporins - therapeutic use
Female
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Pneumonia - drug therapy
Pneumonia - microbiology
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Summary:A prospective, randomized, single-blind comparison of ceftizoxime and cefamandole was conducted in 53 adult patients hospitalized with pneumonia or purulent tracheobronchitis. Twenty-nine of 31 patients treated with ceftizoxime and 15 of 16 patients treated with cefamandole achieved clinical cure. Both antibiotics were well tolerated. The adverse reactions were all minor and did not require discontinuation of therapy in any patient. None of the patients developed a pulmonary suprainfection during therapy with either drug. In this random trial ceftizoxime was as effective as cefamandole for the treatment of lower respiratory tract infections.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/10.suppl_C.215