Pharmacokinetics of clavulanic acid, given in combination with amoxycillin, in volunteers

To study the absorption and disposition of clavulanic acid, ten healthy men received one intravenous and one oral dose of 125 mg clavulanic acid in combination with amoxycillin. Serum and urine concentrations were measured with high-performance liquid chromatography. The mean terminal half-lives in...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1985-10, Vol.16 (4), p.491-498
Main Authors: Nilsson-Ehle, I., Fellner, H., Hedström, S.-Å., Nilsson-Ehle, P., Sjövall, J.
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Amoxicillin - administration & dosage
Amoxicillin - blood
Amoxicillin - metabolism
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Biological Availability
Cimetidine - pharmacology
Clavulanic Acid
Clavulanic Acids - administration & dosage
Clavulanic Acids - blood
Clavulanic Acids - metabolism
Drug Interactions
Female
Half-Life
Humans
Injections, Intravenous
Intestinal Absorption
Kinetics
Male
Medical sciences
Pharmacology. Drug treatments
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To study the absorption and disposition of clavulanic acid, ten healthy men received one intravenous and one oral dose of 125 mg clavulanic acid in combination with amoxycillin. Serum and urine concentrations were measured with high-performance liquid chromatography. The mean terminal half-lives in serum were 0·97 and 0·94 h, respectively. Total serum clearance was 248 ± 55 ml/min × 1·73 m2 Renal clearance was 108 ± 20 and 115 ± 18 ml/min × 1·73 m2 after intravenous and peroral administration. Urinary recovery over 12 h was 49· ± 8·7% of the intravenous and 35·7 ± 13·0% of the oral dose. The bioavailability of the oral dose averaged 60· ± 23·1% but varied considerably (range 31·4–98·8%), indicating very variable absorption from the gastrointestinal tract.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/16.4.491