Amikacin synergism with β-lactam antibiotics against selected nosocomial pathogens

The synergistic interaction between amikacin and several investigational antibiotics against seven different genera of nosocomial pathogens was assessed using the microtitre checkerboard technique. The greatest percentage of tests showing synergy was when amikacin was used in combination with apalci...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1986-03, Vol.17 (3), p.323-326
Main Authors: Gombert, Myles E., Aulicino, Taryn M.
Format: Article
Language:English
Subjects:
Amikacin - pharmacology
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria - drug effects
beta-Lactams
Biological and medical sciences
Cross Infection - microbiology
Drug Resistance, Microbial
Drug Synergism
Gram-Negative Bacteria - drug effects
Humans
Kanamycin - analogs & derivatives
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
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Description
Summary:The synergistic interaction between amikacin and several investigational antibiotics against seven different genera of nosocomial pathogens was assessed using the microtitre checkerboard technique. The greatest percentage of tests showing synergy was when amikacin was used in combination with apalcillin and azlocillin particularly against Serratia marcescens and Proteus spp. When amikacin was combined with several new semi-synthetic cephalosporins, synergy was present in a variable percentage of tests. No antagonism was found in any of the tested combinations.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/17.3.323