Renal function during cefuroxime treatment in patients with pre-existing renal impairment

Glomerular filtration rate measured by 51Chrome-EDTA clearance, serum retention of β2-microglobulin and creatinine and, as a sign of proximal tubular function, urinary loss of β2-microglobulin, were studied in patients with pre-existing renal impairment during treatment with cefuroxime for 2 weeks....

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1980-09, Vol.6 (5), p.665-670
Main Authors: Trollfors, Birger, Suurkula, Madis, Price, John D., Norrby, Ragnar
Format: Article
Language:English
Subjects:
Cefuroxime - adverse effects
Cephaloridine - therapeutic use
Cephalosporins - adverse effects
Edetic Acid
Furosemide - therapeutic use
Gentamicins - therapeutic use
Glomerular Filtration Rate - drug effects
Humans
Kidney - drug effects
Kidney Diseases - complications
Kidney Function Tests
Osteitis - complications
Staphylococcal Infections - drug therapy
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Summary:Glomerular filtration rate measured by 51Chrome-EDTA clearance, serum retention of β2-microglobulin and creatinine and, as a sign of proximal tubular function, urinary loss of β2-microglobulin, were studied in patients with pre-existing renal impairment during treatment with cefuroxime for 2 weeks. There were no signs of nephrotoxicity in 19 out of 20 patients treated with moderately high doses of cefuroxime, with or without concurrent administration of frusemide. Decreased renal function was observed in one patient who had received an overdose of the drug. Renal impairment occurring during treatment with cephaloridine or gentamicin was reversible during subsequent cefuroxime treatment.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/6.5.665