Reduced chioramphenicol-induced damage to DNA

The nitro group of chloramphenicol when electrolytically reduced causes extensive damage to DNA including loss of helix and strand breakage. The process is proposed as a mechanism of chioramphenicol toxicity and may be a contributory factor to chloramphenicol-induced aplastic anaemia.

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1981-06, Vol.7 (6), p.593-597
Main Authors: Skolimowski, Irena M., Rowley, D. A., Knight, R. C., Edwards, D. I.
Format: Article
Language:English
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Description
Summary:The nitro group of chloramphenicol when electrolytically reduced causes extensive damage to DNA including loss of helix and strand breakage. The process is proposed as a mechanism of chioramphenicol toxicity and may be a contributory factor to chloramphenicol-induced aplastic anaemia.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/7.6.593