Virulence of mecillinam-resistant spherical mutants of Klebsiella pneumoniae and Escherichia coli

Mecillinam-resistant spherical mutants of Klebsiella pneumoniae and Escherichia coli were tested for virulence. Measurement of LD5O in mice revealed a slight increase in virulence of the mutant strains. The phagocytosis and killing of the mutant strains by human PMN leucocytes were impaired. We conc...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1982-05, Vol.9 (5), p.379-385
Main Authors: Vught, A. M. J. J. Verweij-van, Namavar, F., Smit, A. M., Sparrius, M., MacLaren, D. M.
Format: Article
Language:English
Subjects:
Amdinocillin - pharmacology
Animals
Escherichia coli - drug effects
Escherichia coli - pathogenicity
Escherichia coli - ultrastructure
Humans
In Vitro Techniques
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - pathogenicity
Klebsiella pneumoniae - ultrastructure
Lethal Dose 50
Mice
Neutrophils - metabolism
Penicillanic Acid - pharmacology
Penicillin Resistance
Phagocytosis
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Summary:Mecillinam-resistant spherical mutants of Klebsiella pneumoniae and Escherichia coli were tested for virulence. Measurement of LD5O in mice revealed a slight increase in virulence of the mutant strains. The phagocytosis and killing of the mutant strains by human PMN leucocytes were impaired. We conclude that mecillinam-resistant mutants, despite their lower growth-rate, may give problems in patients during mecillinam therapy, especially when the defence mechanisms of the body are impaired.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/9.5.379