Pharmacokinetic/pharmacodynamic evaluation of tobramycin dosing in critically ill patients: the Hartford nomogram does not fit

Abstract Objectives Extended-interval dosing of tobramycin is widely applied in patients with the Hartford nomogram as a representative, while this dosing approach has not been extensively evaluated in critically ill patients. The goal of this study was to characterize the pharmacokinetics of tobram...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2021-09, Vol.76 (9), p.2335-2341
Main Authors: Xie, Feifan, Wang, Yan, Peng, Yaru, Cheng, Zeneng, Li, Sanwang
Format: Article
Language:English
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Summary:Abstract Objectives Extended-interval dosing of tobramycin is widely applied in patients with the Hartford nomogram as a representative, while this dosing approach has not been extensively evaluated in critically ill patients. The goal of this study was to characterize the pharmacokinetics of tobramycin and to evaluate the appropriateness of the Hartford nomogram in critically ill patients. Methods A retrospective analysis was performed based on a medical critical care database. The extracted concentration data of tobramycin were used for the construction of the population pharmacokinetic model using a non-linear mixed-effects modelling approach. Real-world data-based simulations were conducted to evaluate the pharmacodynamic target attainment (Cmax/MIC ≥10) and safety (concentration
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkab164