Support for higher ciprofloxacin AUC24/MIC targets in treating Enterobacteriaceae bloodstream infection

Objectives Given concerns regarding optimal therapy for serious Gram-negative infections, the goal was to characterize the pharmacodynamics of ciprofloxacin in the context of treating bloodstream infection. Patients and methods Data were collected from the medical records of 178 clinical cases. Bloo...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2010-08, Vol.65 (8), p.1725-1732
Main Authors: Zelenitsky, Sheryl A., Ariano, Robert E.
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
fluoroquinolones
Human bacterial diseases
Infectious diseases
Medical sciences
pharmacodynamics
pharmacokinetics
Pharmacology. Drug treatments
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Summary:Objectives Given concerns regarding optimal therapy for serious Gram-negative infections, the goal was to characterize the pharmacodynamics of ciprofloxacin in the context of treating bloodstream infection. Patients and methods Data were collected from the medical records of 178 clinical cases. Blood isolates were retrieved and ciprofloxacin MICs were measured. Forty-two cases in which ciprofloxacin was initiated within 24 h of the positive blood culture were used in the pharmacodynamic analysis. Results Significant factors with regard to treatment failure were low ciprofloxacin AUC24/MIC (P 
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkq211