Pharmacokinetics of trimethoprim/sulfametrole in critically ill patients on continuous renal replacement therapy

Abstract Objectives We investigated the effect of continuous renal replacement therapy (CRRT) on the pharmacokinetics of trimethoprim and sulfametrole. Patients and methods We enrolled critically ill adults undergoing CRRT and critically ill adults with normal or slightly impaired renal function (pl...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2020-05, Vol.75 (5), p.1237-1241
Main Authors: Welte, René, Beyer, Rudolph, Hotter, Johannes, Broeker, Astrid, Wicha, Sebastian G, Gasperetti, Tiziana, Ranke, Paul, Zaruba, Marc-Michael, Lorenz, Ingo, Eschertzhuber, Stephan, Ströhle, Mathias, Bellmann-Weiler, Rosa, Joannidis, Michael, Bellmann, Romuald
Format: Article
Language:English
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Summary:Abstract Objectives We investigated the effect of continuous renal replacement therapy (CRRT) on the pharmacokinetics of trimethoprim and sulfametrole. Patients and methods We enrolled critically ill adults undergoing CRRT and critically ill adults with normal or slightly impaired renal function (plasma creatinine concentration
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkz556