Assessment of Tobacco Exposure During Pregnancy by Meconium Analysis and Maternal Interview

Abstract Smoking during pregnancy can have serious obstetric and fetal complications. Therefore, it is essential to identify in utero exposure to tobacco, being meconium the matrix of choice for this purpose. Meconium (n = 565) was analyzed for nicotine, cotinine and hydroxycotinine by LC–MS-MS. The...

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Published in:Journal of analytical toxicology 2020-12, Vol.44 (8), p.797-802
Main Authors: López-Rabuñal, Ángela, Lendoiro, Elena, González-Colmenero, Eva, Concheiro-Guisán, Ana, Concheiro-Guisán, Marta, Peñas-Silva, Patricia, Macias-Cortiña, Manuel, López-Rivadulla, Manuel, Cruz, Angelines, de-Castro-Ríos, Ana
Format: Article
Language:English
Subjects:
Chromatography, Liquid
Cotinine - analogs & derivatives
Cotinine - metabolism
Female
Humans
Infant, Newborn
Male
Mass Spectrometry
Maternal Exposure - statistics & numerical data
Meconium - metabolism
Nicotine - metabolism
Pregnancy
Tobacco Smoke Pollution - statistics & numerical data
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Summary:Abstract Smoking during pregnancy can have serious obstetric and fetal complications. Therefore, it is essential to identify in utero exposure to tobacco, being meconium the matrix of choice for this purpose. Meconium (n = 565) was analyzed for nicotine, cotinine and hydroxycotinine by LC–MS-MS. Then, tobacco meconium results were compared with smoking habits during pregnancy and neonatal outcomes measures (birth weight, length, head circumference, gestational age and Apgar scores). Although meconium analysis increased identification of in-utero exposure to tobacco (17.7% meconium positive specimens vs 13.5% mothers admitting tobacco use during pregnancy), there was a statistically significant relationship between meconium results and interview answers (P 
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/bkaa027