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Clinical Presentation, Autopsy Results and Toxicology Findings in an Acute N-Ethylpentylone Fatality

The clinical presentation, autopsy findings and toxicology results in an acute fatality involving N-ethylpentylone, a new cathinone derivative, are described. Law enforcement transported a male who was agitated and exhibiting unusual behavior to a local hospital. Upon arrival at the hospital, his bo...

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Published in:Journal of analytical toxicology 2017-05, Vol.41 (4), p.342
Main Authors: Thirakul, Phoutthasone, S Hair, Laura, L Bergen, Kirstin, M Pearson, Julia
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Language:English
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description The clinical presentation, autopsy findings and toxicology results in an acute fatality involving N-ethylpentylone, a new cathinone derivative, are described. Law enforcement transported a male who was agitated and exhibiting unusual behavior to a local hospital. Upon arrival at the hospital, his body temperature was 105.5 degrees Fahrenheit and his blood pH was 6.7. Clinical laboratory analysis revealed elevated troponins, rhabdomyolysis, hypoglycemia, hepatic and renal injury, respiratory failure and disseminated intravascular coagulation. He was intubated and admitted to the intensive care unit, treated with cooling blankets, bicarbonate and intravenous fluids. Despite medical treatment, he went into cardiac arrest and was pronounced dead ~36 h after admission. Autopsy findings identified some abrasions on his arms and legs, a bloody nose and a mildly enlarged heart. Antemortem blood was analyzed by gas chromatography coupled with a mass spectrometer which identified N-ethylpentylone. Based on clinical presentation, autopsy findings and toxicology results, the medical examiner concluded the cause of death was intoxication by N-ethylpentylone and the manner of death was accident.
doi_str_mv 10.1093/jat/bkx004
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ispartof Journal of analytical toxicology, 2017-05, Vol.41 (4), p.342
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source Oxford Journals Online; Alma/SFX Local Collection
subjects Autopsy
Benzodioxoles - blood
Benzodioxoles - toxicity
Butylamines - blood
Butylamines - toxicity
Central Nervous System Stimulants - blood
Central Nervous System Stimulants - toxicity
Fever
Forensic Toxicology
Heart Arrest
Humans
Male
title Clinical Presentation, Autopsy Results and Toxicology Findings in an Acute N-Ethylpentylone Fatality
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