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Clinical Presentation, Autopsy Results and Toxicology Findings in an Acute N-Ethylpentylone Fatality
The clinical presentation, autopsy findings and toxicology results in an acute fatality involving N-ethylpentylone, a new cathinone derivative, are described. Law enforcement transported a male who was agitated and exhibiting unusual behavior to a local hospital. Upon arrival at the hospital, his bo...
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Published in: | Journal of analytical toxicology 2017-05, Vol.41 (4), p.342 |
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container_title | Journal of analytical toxicology |
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creator | Thirakul, Phoutthasone S Hair, Laura L Bergen, Kirstin M Pearson, Julia |
description | The clinical presentation, autopsy findings and toxicology results in an acute fatality involving N-ethylpentylone, a new cathinone derivative, are described. Law enforcement transported a male who was agitated and exhibiting unusual behavior to a local hospital. Upon arrival at the hospital, his body temperature was 105.5 degrees Fahrenheit and his blood pH was 6.7. Clinical laboratory analysis revealed elevated troponins, rhabdomyolysis, hypoglycemia, hepatic and renal injury, respiratory failure and disseminated intravascular coagulation. He was intubated and admitted to the intensive care unit, treated with cooling blankets, bicarbonate and intravenous fluids. Despite medical treatment, he went into cardiac arrest and was pronounced dead ~36 h after admission. Autopsy findings identified some abrasions on his arms and legs, a bloody nose and a mildly enlarged heart. Antemortem blood was analyzed by gas chromatography coupled with a mass spectrometer which identified N-ethylpentylone. Based on clinical presentation, autopsy findings and toxicology results, the medical examiner concluded the cause of death was intoxication by N-ethylpentylone and the manner of death was accident. |
doi_str_mv | 10.1093/jat/bkx004 |
format | article |
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Law enforcement transported a male who was agitated and exhibiting unusual behavior to a local hospital. Upon arrival at the hospital, his body temperature was 105.5 degrees Fahrenheit and his blood pH was 6.7. Clinical laboratory analysis revealed elevated troponins, rhabdomyolysis, hypoglycemia, hepatic and renal injury, respiratory failure and disseminated intravascular coagulation. He was intubated and admitted to the intensive care unit, treated with cooling blankets, bicarbonate and intravenous fluids. Despite medical treatment, he went into cardiac arrest and was pronounced dead ~36 h after admission. Autopsy findings identified some abrasions on his arms and legs, a bloody nose and a mildly enlarged heart. Antemortem blood was analyzed by gas chromatography coupled with a mass spectrometer which identified N-ethylpentylone. Based on clinical presentation, autopsy findings and toxicology results, the medical examiner concluded the cause of death was intoxication by N-ethylpentylone and the manner of death was accident.</description><identifier>ISSN: 0146-4760</identifier><identifier>EISSN: 1945-2403</identifier><identifier>DOI: 10.1093/jat/bkx004</identifier><identifier>PMID: 28137731</identifier><language>eng</language><publisher>England</publisher><subject>Autopsy ; Benzodioxoles - blood ; Benzodioxoles - toxicity ; Butylamines - blood ; Butylamines - toxicity ; Central Nervous System Stimulants - blood ; Central Nervous System Stimulants - toxicity ; Fever ; Forensic Toxicology ; Heart Arrest ; Humans ; Male</subject><ispartof>Journal of analytical toxicology, 2017-05, Vol.41 (4), p.342</ispartof><rights>The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c287t-9d778ad0daac77155d7418d5a0dfa8b39358150e768c6b3d171adbd6c3d46a83</citedby><cites>FETCH-LOGICAL-c287t-9d778ad0daac77155d7418d5a0dfa8b39358150e768c6b3d171adbd6c3d46a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28137731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thirakul, Phoutthasone</creatorcontrib><creatorcontrib>S Hair, Laura</creatorcontrib><creatorcontrib>L Bergen, Kirstin</creatorcontrib><creatorcontrib>M Pearson, Julia</creatorcontrib><title>Clinical Presentation, Autopsy Results and Toxicology Findings in an Acute N-Ethylpentylone Fatality</title><title>Journal of analytical toxicology</title><addtitle>J Anal Toxicol</addtitle><description>The clinical presentation, autopsy findings and toxicology results in an acute fatality involving N-ethylpentylone, a new cathinone derivative, are described. Law enforcement transported a male who was agitated and exhibiting unusual behavior to a local hospital. Upon arrival at the hospital, his body temperature was 105.5 degrees Fahrenheit and his blood pH was 6.7. Clinical laboratory analysis revealed elevated troponins, rhabdomyolysis, hypoglycemia, hepatic and renal injury, respiratory failure and disseminated intravascular coagulation. He was intubated and admitted to the intensive care unit, treated with cooling blankets, bicarbonate and intravenous fluids. Despite medical treatment, he went into cardiac arrest and was pronounced dead ~36 h after admission. Autopsy findings identified some abrasions on his arms and legs, a bloody nose and a mildly enlarged heart. Antemortem blood was analyzed by gas chromatography coupled with a mass spectrometer which identified N-ethylpentylone. Based on clinical presentation, autopsy findings and toxicology results, the medical examiner concluded the cause of death was intoxication by N-ethylpentylone and the manner of death was accident.</description><subject>Autopsy</subject><subject>Benzodioxoles - blood</subject><subject>Benzodioxoles - toxicity</subject><subject>Butylamines - blood</subject><subject>Butylamines - toxicity</subject><subject>Central Nervous System Stimulants - blood</subject><subject>Central Nervous System Stimulants - toxicity</subject><subject>Fever</subject><subject>Forensic Toxicology</subject><subject>Heart Arrest</subject><subject>Humans</subject><subject>Male</subject><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNo9kEFLwzAYhoMobk4v_gDJWaxLljRJj2NsKgwV2b18TbKZmaWlSWH991amnt7D-_AcHoRuKXmkpGDTPaRp9XUkhJ-hMS14ns04YedoTCgXGZeCjNBVjHtCqFCCXaLRTFEmJaNjZBbeBafB4_fWRhsSJFeHBzzvUt3EHn_Y2PkUMQSDN_XR6drXux6vXDAu7CJ2YbjwXHfJ4tdsmT573wyW3tfB4hUk8C711-hiCz7am9-doM1quVk8Z-u3p5fFfJ3pmZIpK4yUCgwxAFpKmudGcqpMDsRsQVWsYLmiObFSKC0qZqikYCojNDNcgGITdH_S6raOsbXbsmndAdq-pKT8KVUOpcpTqQG-O8FNVx2s-Uf_0rBvQUVm4A</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Thirakul, Phoutthasone</creator><creator>S Hair, Laura</creator><creator>L Bergen, Kirstin</creator><creator>M Pearson, Julia</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20170501</creationdate><title>Clinical Presentation, Autopsy Results and Toxicology Findings in an Acute N-Ethylpentylone Fatality</title><author>Thirakul, Phoutthasone ; S Hair, Laura ; L Bergen, Kirstin ; M Pearson, Julia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-9d778ad0daac77155d7418d5a0dfa8b39358150e768c6b3d171adbd6c3d46a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Autopsy</topic><topic>Benzodioxoles - blood</topic><topic>Benzodioxoles - toxicity</topic><topic>Butylamines - blood</topic><topic>Butylamines - toxicity</topic><topic>Central Nervous System Stimulants - blood</topic><topic>Central Nervous System Stimulants - toxicity</topic><topic>Fever</topic><topic>Forensic Toxicology</topic><topic>Heart Arrest</topic><topic>Humans</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thirakul, Phoutthasone</creatorcontrib><creatorcontrib>S Hair, Laura</creatorcontrib><creatorcontrib>L Bergen, Kirstin</creatorcontrib><creatorcontrib>M Pearson, Julia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thirakul, Phoutthasone</au><au>S Hair, Laura</au><au>L Bergen, Kirstin</au><au>M Pearson, Julia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Presentation, Autopsy Results and Toxicology Findings in an Acute N-Ethylpentylone Fatality</atitle><jtitle>Journal of analytical toxicology</jtitle><addtitle>J Anal Toxicol</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>41</volume><issue>4</issue><spage>342</spage><pages>342-</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><abstract>The clinical presentation, autopsy findings and toxicology results in an acute fatality involving N-ethylpentylone, a new cathinone derivative, are described. Law enforcement transported a male who was agitated and exhibiting unusual behavior to a local hospital. Upon arrival at the hospital, his body temperature was 105.5 degrees Fahrenheit and his blood pH was 6.7. Clinical laboratory analysis revealed elevated troponins, rhabdomyolysis, hypoglycemia, hepatic and renal injury, respiratory failure and disseminated intravascular coagulation. He was intubated and admitted to the intensive care unit, treated with cooling blankets, bicarbonate and intravenous fluids. Despite medical treatment, he went into cardiac arrest and was pronounced dead ~36 h after admission. Autopsy findings identified some abrasions on his arms and legs, a bloody nose and a mildly enlarged heart. Antemortem blood was analyzed by gas chromatography coupled with a mass spectrometer which identified N-ethylpentylone. Based on clinical presentation, autopsy findings and toxicology results, the medical examiner concluded the cause of death was intoxication by N-ethylpentylone and the manner of death was accident.</abstract><cop>England</cop><pmid>28137731</pmid><doi>10.1093/jat/bkx004</doi></addata></record> |
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ispartof | Journal of analytical toxicology, 2017-05, Vol.41 (4), p.342 |
issn | 0146-4760 1945-2403 |
language | eng |
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source | Oxford Journals Online; Alma/SFX Local Collection |
subjects | Autopsy Benzodioxoles - blood Benzodioxoles - toxicity Butylamines - blood Butylamines - toxicity Central Nervous System Stimulants - blood Central Nervous System Stimulants - toxicity Fever Forensic Toxicology Heart Arrest Humans Male |
title | Clinical Presentation, Autopsy Results and Toxicology Findings in an Acute N-Ethylpentylone Fatality |
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