Failure off Inoculation With Polyoma Virus To Influence Chemical Carcinogenesis in Mice

Because inoculation with the polyoma virus will protect adult mice against growth of a relatively small number of cells of transplantable polyoma-induced tumors and because the immunity apparently is not due to the virus per se but to an altered cell antigen, it seemed pertinent to determine whether...

Full description

Saved in:
Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1963-01, Vol.30 (1), p.203-206
Main Authors: Malmgren, Richard A., Rabson, Alan S.
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 206
container_issue 1
container_start_page 203
container_title JNCI : Journal of the National Cancer Institute
container_volume 30
creator Malmgren, Richard A.
Rabson, Alan S.
description Because inoculation with the polyoma virus will protect adult mice against growth of a relatively small number of cells of transplantable polyoma-induced tumors and because the immunity apparently is not due to the virus per se but to an altered cell antigen, it seemed pertinent to determine whether inoculation with the polyoma virus would also protect against chemical carcinogenesis. C3H/HeN female mice, treated with 3-methylcholanthrene by subcutaneous injection or skin painting, developed the same number of tumors and at the same rate in polyoma-virus infected and uninfected animals. A/LN male mice treated with urethan developed the same number of lung tumors in polyoma-virus infected and uninfected animals. Polyoma virus infection therefore did not interfere with or protect against chemical carcinogenesis.
doi_str_mv 10.1093/jnci/30.1.203
format article
fullrecord <record><control><sourceid>istex_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_jnci_30_1_203</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ark_67375_HXZ_8JB6LVX6_X</sourcerecordid><originalsourceid>FETCH-LOGICAL-c146t-535a6e7f29259345555433d903a7722dfcb046f8ac0550d53cfc3ab0255fe7bd3</originalsourceid><addsrcrecordid>eNpFkFFLwzAUhYMoOKePvucPdEtzm6Z91OLcZKIPcxu-hCxNXGbXSNLC9u_NUPS8XA58HC4fQrcpGaWkhPGuVXYMsYwogTM0SLOcJDQl7BwNCKE8KQqeXaKrEHYkpqTZAK0m0ja919gZg2etU30jO-tavLLdFr-65uj2Ei-t7wNeuEiYptet0rja6r1VssGV9Mq27kO3OtiAbYufrdLX6MLIJuib3ztEb5OHRTVN5i-Ps-punqj4XZcwYDLX3NCSshIyFpMB1CUByTmltVEbkuWmkIowRmoGyiiQG0IZM5pvahii5GdXeReC10Z8ebuX_ihSIk5WxMmKgFhEtPLP29Dpwx8s_afIOXAmput3UTzd5_PlOhdr-AZ_kGUz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Failure off Inoculation With Polyoma Virus To Influence Chemical Carcinogenesis in Mice</title><source>Oxford University Press Archive</source><creator>Malmgren, Richard A. ; Rabson, Alan S.</creator><creatorcontrib>Malmgren, Richard A. ; Rabson, Alan S.</creatorcontrib><description>Because inoculation with the polyoma virus will protect adult mice against growth of a relatively small number of cells of transplantable polyoma-induced tumors and because the immunity apparently is not due to the virus per se but to an altered cell antigen, it seemed pertinent to determine whether inoculation with the polyoma virus would also protect against chemical carcinogenesis. C3H/HeN female mice, treated with 3-methylcholanthrene by subcutaneous injection or skin painting, developed the same number of tumors and at the same rate in polyoma-virus infected and uninfected animals. A/LN male mice treated with urethan developed the same number of lung tumors in polyoma-virus infected and uninfected animals. Polyoma virus infection therefore did not interfere with or protect against chemical carcinogenesis.</description><identifier>ISSN: 0027-8874</identifier><identifier>ISSN: 1460-2105</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/30.1.203</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>JNCI : Journal of the National Cancer Institute, 1963-01, Vol.30 (1), p.203-206</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids></links><search><creatorcontrib>Malmgren, Richard A.</creatorcontrib><creatorcontrib>Rabson, Alan S.</creatorcontrib><title>Failure off Inoculation With Polyoma Virus To Influence Chemical Carcinogenesis in Mice</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>Because inoculation with the polyoma virus will protect adult mice against growth of a relatively small number of cells of transplantable polyoma-induced tumors and because the immunity apparently is not due to the virus per se but to an altered cell antigen, it seemed pertinent to determine whether inoculation with the polyoma virus would also protect against chemical carcinogenesis. C3H/HeN female mice, treated with 3-methylcholanthrene by subcutaneous injection or skin painting, developed the same number of tumors and at the same rate in polyoma-virus infected and uninfected animals. A/LN male mice treated with urethan developed the same number of lung tumors in polyoma-virus infected and uninfected animals. Polyoma virus infection therefore did not interfere with or protect against chemical carcinogenesis.</description><issn>0027-8874</issn><issn>1460-2105</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1963</creationdate><recordtype>article</recordtype><recordid>eNpFkFFLwzAUhYMoOKePvucPdEtzm6Z91OLcZKIPcxu-hCxNXGbXSNLC9u_NUPS8XA58HC4fQrcpGaWkhPGuVXYMsYwogTM0SLOcJDQl7BwNCKE8KQqeXaKrEHYkpqTZAK0m0ja919gZg2etU30jO-tavLLdFr-65uj2Ei-t7wNeuEiYptet0rja6r1VssGV9Mq27kO3OtiAbYufrdLX6MLIJuib3ztEb5OHRTVN5i-Ps-punqj4XZcwYDLX3NCSshIyFpMB1CUByTmltVEbkuWmkIowRmoGyiiQG0IZM5pvahii5GdXeReC10Z8ebuX_ihSIk5WxMmKgFhEtPLP29Dpwx8s_afIOXAmput3UTzd5_PlOhdr-AZ_kGUz</recordid><startdate>196301</startdate><enddate>196301</enddate><creator>Malmgren, Richard A.</creator><creator>Rabson, Alan S.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>196301</creationdate><title>Failure off Inoculation With Polyoma Virus To Influence Chemical Carcinogenesis in Mice</title><author>Malmgren, Richard A. ; Rabson, Alan S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c146t-535a6e7f29259345555433d903a7722dfcb046f8ac0550d53cfc3ab0255fe7bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1963</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malmgren, Richard A.</creatorcontrib><creatorcontrib>Rabson, Alan S.</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malmgren, Richard A.</au><au>Rabson, Alan S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Failure off Inoculation With Polyoma Virus To Influence Chemical Carcinogenesis in Mice</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1963-01</date><risdate>1963</risdate><volume>30</volume><issue>1</issue><spage>203</spage><epage>206</epage><pages>203-206</pages><issn>0027-8874</issn><issn>1460-2105</issn><eissn>1460-2105</eissn><abstract>Because inoculation with the polyoma virus will protect adult mice against growth of a relatively small number of cells of transplantable polyoma-induced tumors and because the immunity apparently is not due to the virus per se but to an altered cell antigen, it seemed pertinent to determine whether inoculation with the polyoma virus would also protect against chemical carcinogenesis. C3H/HeN female mice, treated with 3-methylcholanthrene by subcutaneous injection or skin painting, developed the same number of tumors and at the same rate in polyoma-virus infected and uninfected animals. A/LN male mice treated with urethan developed the same number of lung tumors in polyoma-virus infected and uninfected animals. Polyoma virus infection therefore did not interfere with or protect against chemical carcinogenesis.</abstract><pub>Oxford University Press</pub><doi>10.1093/jnci/30.1.203</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0027-8874
ispartof JNCI : Journal of the National Cancer Institute, 1963-01, Vol.30 (1), p.203-206
issn 0027-8874
1460-2105
1460-2105
language eng
recordid cdi_crossref_primary_10_1093_jnci_30_1_203
source Oxford University Press Archive
title Failure off Inoculation With Polyoma Virus To Influence Chemical Carcinogenesis in Mice
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T14%3A34%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-istex_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Failure%20off%20Inoculation%20With%20Polyoma%20Virus%20To%20Influence%20Chemical%20Carcinogenesis%20in%20Mice&rft.jtitle=JNCI%20:%20Journal%20of%20the%20National%20Cancer%20Institute&rft.au=Malmgren,%20Richard%20A.&rft.date=1963-01&rft.volume=30&rft.issue=1&rft.spage=203&rft.epage=206&rft.pages=203-206&rft.issn=0027-8874&rft.eissn=1460-2105&rft_id=info:doi/10.1093/jnci/30.1.203&rft_dat=%3Cistex_cross%3Eark_67375_HXZ_8JB6LVX6_X%3C/istex_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c146t-535a6e7f29259345555433d903a7722dfcb046f8ac0550d53cfc3ab0255fe7bd3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true