In Vitro Viral Transformation off Chemically Transformed Cells

Hamster embryonic cells grown in a suspension of 3-methyl-cholanthrene underwent neoplastic transformation. These cells, when injected into homologous hosts, could produce tumors, but morphologic change in vitro was not significant. When these transformed cells were exposed to simian virus 40 or the...

Full description

Saved in:
Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1968-04, Vol.40 (4), p.757-770
Main Authors: DiPaolo, Joseph A., Rabson, Alan S., Malmgren, Richard A.
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 770
container_issue 4
container_start_page 757
container_title JNCI : Journal of the National Cancer Institute
container_volume 40
creator DiPaolo, Joseph A.
Rabson, Alan S.
Malmgren, Richard A.
description Hamster embryonic cells grown in a suspension of 3-methyl-cholanthrene underwent neoplastic transformation. These cells, when injected into homologous hosts, could produce tumors, but morphologic change in vitro was not significant. When these transformed cells were exposed to simian virus 40 or the LLE 46 strain of adenovirus 7 (the SV40-adenovirus 7 “hybrid”), they were further transformed with altered morphologic and growth characteristics in vitro, chromosomal changes, appearance of intranuclear SV40 T antigen, and changes in the morphology of tumors produced by injection of cells into homologous hosts.
doi_str_mv 10.1093/jnci/40.4.757
format article
fullrecord <record><control><sourceid>istex_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_jnci_40_4_757</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ark_67375_HXZ_DTMGSKX6_1</sourcerecordid><originalsourceid>FETCH-LOGICAL-c144t-32d94908f35b3d1403b502602700e99ee6156c05a0fd08436e9ce145a5aa50993</originalsourceid><addsrcrecordid>eNpFjz1PwzAQhi0EEqEwsucPJD3HZydekFCAtqKIgYAqFst1bJGSD2RnoP-eVCD6DvcO9-h0DyHXFFIKks13vWnmCCmmOc9PSERRQJJR4KckAsjypChyPCcXIexgiswwIjerPn5rRj9M0-s2rrzugxt8p8dm6OPBubj8sF1jdNvuj1tbx6Vt23BJzpxug7366xl5fbivymWyfl6sytt1YijimLCsliihcIxvWU0R2JZDJqafAKyU1grKhQGuwdVQIBNWGkuRa641BynZjCS_d40fQvDWqS_fdNrvFQV1kFcHeYWgUE3yR74Jo_3-h7X_VCJnOVfLzbu6q54WL48boSj7AXr3W7c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>In Vitro Viral Transformation off Chemically Transformed Cells</title><source>Oxford University Press Archive</source><creator>DiPaolo, Joseph A. ; Rabson, Alan S. ; Malmgren, Richard A.</creator><creatorcontrib>DiPaolo, Joseph A. ; Rabson, Alan S. ; Malmgren, Richard A.</creatorcontrib><description>Hamster embryonic cells grown in a suspension of 3-methyl-cholanthrene underwent neoplastic transformation. These cells, when injected into homologous hosts, could produce tumors, but morphologic change in vitro was not significant. When these transformed cells were exposed to simian virus 40 or the LLE 46 strain of adenovirus 7 (the SV40-adenovirus 7 “hybrid”), they were further transformed with altered morphologic and growth characteristics in vitro, chromosomal changes, appearance of intranuclear SV40 T antigen, and changes in the morphology of tumors produced by injection of cells into homologous hosts.</description><identifier>ISSN: 0027-8874</identifier><identifier>ISSN: 1460-2105</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/40.4.757</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>JNCI : Journal of the National Cancer Institute, 1968-04, Vol.40 (4), p.757-770</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>DiPaolo, Joseph A.</creatorcontrib><creatorcontrib>Rabson, Alan S.</creatorcontrib><creatorcontrib>Malmgren, Richard A.</creatorcontrib><title>In Vitro Viral Transformation off Chemically Transformed Cells</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>Hamster embryonic cells grown in a suspension of 3-methyl-cholanthrene underwent neoplastic transformation. These cells, when injected into homologous hosts, could produce tumors, but morphologic change in vitro was not significant. When these transformed cells were exposed to simian virus 40 or the LLE 46 strain of adenovirus 7 (the SV40-adenovirus 7 “hybrid”), they were further transformed with altered morphologic and growth characteristics in vitro, chromosomal changes, appearance of intranuclear SV40 T antigen, and changes in the morphology of tumors produced by injection of cells into homologous hosts.</description><issn>0027-8874</issn><issn>1460-2105</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><recordid>eNpFjz1PwzAQhi0EEqEwsucPJD3HZydekFCAtqKIgYAqFst1bJGSD2RnoP-eVCD6DvcO9-h0DyHXFFIKks13vWnmCCmmOc9PSERRQJJR4KckAsjypChyPCcXIexgiswwIjerPn5rRj9M0-s2rrzugxt8p8dm6OPBubj8sF1jdNvuj1tbx6Vt23BJzpxug7366xl5fbivymWyfl6sytt1YijimLCsliihcIxvWU0R2JZDJqafAKyU1grKhQGuwdVQIBNWGkuRa641BynZjCS_d40fQvDWqS_fdNrvFQV1kFcHeYWgUE3yR74Jo_3-h7X_VCJnOVfLzbu6q54WL48boSj7AXr3W7c</recordid><startdate>196804</startdate><enddate>196804</enddate><creator>DiPaolo, Joseph A.</creator><creator>Rabson, Alan S.</creator><creator>Malmgren, Richard A.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>196804</creationdate><title>In Vitro Viral Transformation off Chemically Transformed Cells</title><author>DiPaolo, Joseph A. ; Rabson, Alan S. ; Malmgren, Richard A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c144t-32d94908f35b3d1403b502602700e99ee6156c05a0fd08436e9ce145a5aa50993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DiPaolo, Joseph A.</creatorcontrib><creatorcontrib>Rabson, Alan S.</creatorcontrib><creatorcontrib>Malmgren, Richard A.</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DiPaolo, Joseph A.</au><au>Rabson, Alan S.</au><au>Malmgren, Richard A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro Viral Transformation off Chemically Transformed Cells</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1968-04</date><risdate>1968</risdate><volume>40</volume><issue>4</issue><spage>757</spage><epage>770</epage><pages>757-770</pages><issn>0027-8874</issn><issn>1460-2105</issn><eissn>1460-2105</eissn><abstract>Hamster embryonic cells grown in a suspension of 3-methyl-cholanthrene underwent neoplastic transformation. These cells, when injected into homologous hosts, could produce tumors, but morphologic change in vitro was not significant. When these transformed cells were exposed to simian virus 40 or the LLE 46 strain of adenovirus 7 (the SV40-adenovirus 7 “hybrid”), they were further transformed with altered morphologic and growth characteristics in vitro, chromosomal changes, appearance of intranuclear SV40 T antigen, and changes in the morphology of tumors produced by injection of cells into homologous hosts.</abstract><pub>Oxford University Press</pub><doi>10.1093/jnci/40.4.757</doi><tpages>14</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0027-8874
ispartof JNCI : Journal of the National Cancer Institute, 1968-04, Vol.40 (4), p.757-770
issn 0027-8874
1460-2105
1460-2105
language eng
recordid cdi_crossref_primary_10_1093_jnci_40_4_757
source Oxford University Press Archive
title In Vitro Viral Transformation off Chemically Transformed Cells
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T11%3A34%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-istex_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20Vitro%20Viral%20Transformation%20off%20Chemically%20Transformed%20Cells&rft.jtitle=JNCI%20:%20Journal%20of%20the%20National%20Cancer%20Institute&rft.au=DiPaolo,%20Joseph%20A.&rft.date=1968-04&rft.volume=40&rft.issue=4&rft.spage=757&rft.epage=770&rft.pages=757-770&rft.issn=0027-8874&rft.eissn=1460-2105&rft_id=info:doi/10.1093/jnci/40.4.757&rft_dat=%3Cistex_cross%3Eark_67375_HXZ_DTMGSKX6_1%3C/istex_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c144t-32d94908f35b3d1403b502602700e99ee6156c05a0fd08436e9ce145a5aa50993%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true