Growth of Carcinomas in the Region of the Cartilage

Carcinomas were induced in CFLP mice after application of an acetone solution of benzo[a]pyrene to the skin of the external auricle. Histologic preparations were examined of all tumors and the surrounding cartilage for study of the pattern of tumor growth in connection with the cartilage. Of 100 ani...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1973-01, Vol.50 (1), p.291-293
Main Authors: Dontenwill, W., Chevalier, H.-J., Reckzeh, G.
Format: Article
Language:English
Subjects:
Animals
Benzopyrenes
Carcinoma - chemically induced
Carcinoma - pathology
Cartilage - pathology
Cricetinae
Ear Neoplasms - chemically induced
Ear Neoplasms - pathology
Ear, External - pathology
Female
Mice
Neoplasms, Experimental - chemically induced
Neoplasms, Experimental - pathology
Tracheal Neoplasms - pathology
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Summary:Carcinomas were induced in CFLP mice after application of an acetone solution of benzo[a]pyrene to the skin of the external auricle. Histologic preparations were examined of all tumors and the surrounding cartilage for study of the pattern of tumor growth in connection with the cartilage. Of 100 animals, 81 developed carcinomas, up to walnut size, enveloping the cartilage but never infiltrating the bridges of the cartilage of the ear. The cartilage had a high resistance for carcinoma infiltration. The findings were discussed in connection with carcinoma infiltration into the respiratory tract of the golden hamster.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/50.1.291