Effect of Three Strains of BeG Against a Murine Leukemia After Drug Therapy

Three strains of Mycobacterium bovis (BCG) of varying virulence were grown under identical conditions and tested for efficacy in chemoimmunostimulation of a murine leukemia. Equal numbers of viable organisms of the Pasteur, Japan, and Brazil strains of BCG were equally effective, after chemotherapy,...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1973-12, Vol.51 (6), p.2001-2003
Main Authors: Sher, Neal A., Pearson, John W., Chaparas, Sotiros D., Chirigos, Michael A.
Format: Article
Language:English
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Summary:Three strains of Mycobacterium bovis (BCG) of varying virulence were grown under identical conditions and tested for efficacy in chemoimmunostimulation of a murine leukemia. Equal numbers of viable organisms of the Pasteur, Japan, and Brazil strains of BCG were equally effective, after chemotherapy, in producing a high percentage of long-term survivors (82%) compared to groups of animals treated with chemotherapy (40%) or BCG alone (3%).
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/51.6.2001