Rapidly Acquired Cytotoxicity of Lymphoid Cells From Mice Inoculated With Allogeneic Spleen Cells

Spleen cells from C57BL/6J or CBA mice inoculated iv with spleen cells from BALB/c mice produced a strong nonspecific cytotoxic effect on target cells {mouse L-cells). Lymph node cells from CBA or C57BL/6J mice inoculated sc with BALB/c spleen cells also destroyed L-cells. Lymph node cells from mice...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1976-12, Vol.57 (6), p.1233-1236
Main Authors: Slavina, Elena G., Karmanova, Natalia V., Leipunskaya, Inna L., Zinzar, Svetlana N., Reinhöfer, Jurgen, Svet-Moldavsky, George J.
Format: Article
Language:English
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Summary:Spleen cells from C57BL/6J or CBA mice inoculated iv with spleen cells from BALB/c mice produced a strong nonspecific cytotoxic effect on target cells {mouse L-cells). Lymph node cells from CBA or C57BL/6J mice inoculated sc with BALB/c spleen cells also destroyed L-cells. Lymph node cells from mice inoculated with syngeneic spleen cells were not cytotoxic. The cytotoxic effect was observed if recipient spleens or lymph nodes were removed 1, 4, 6, 9, and 18 hours after injection of allogeneic but not syngeneic spleen cells. This effect was considerably reduced or completely suppressed after partial or total removal of plastic-adherent cells.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/57.6.1233