Cancer Incidence After Radiotherapy for Skin Hemangioma: A Retrospective Cohort Study in Sweden

The cancer incidence was studied in 18, 030 patients (33% males, 67% females) with skin hemangioma who were admitted to Radiumhemmet, Karolinska Hospital, Stockholm, Sweden, 1920–1959. Radium-226 sources were used in 12, 821 patients, x-ray therapy was used in 2, 515 patients, and no radiotherapy wa...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1988-11, Vol.80 (17), p.1387-1392
Main Authors: Fürst, Carl Johan, Lundell, Marie, Holm, Lars-Erik, Silfversward, Claes
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Breast - radiation effects
Dermatology
Female
Hemangioma - radiotherapy
Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue
Humans
Male
Medical sciences
Neoplasms, Radiation-Induced - epidemiology
Radiotherapy - adverse effects
Retrospective Studies
Risk Factors
Skin Neoplasms - radiotherapy
Sweden
Time Factors
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Summary:The cancer incidence was studied in 18, 030 patients (33% males, 67% females) with skin hemangioma who were admitted to Radiumhemmet, Karolinska Hospital, Stockholm, Sweden, 1920–1959. Radium-226 sources were used in 12, 821 patients, x-ray therapy was used in 2, 515 patients, and no radiotherapy was given to 2, 694 patients. Cancer incidence in the cohort was researched by record linkage with the Swedish Cancer Register for the period 1958–1982. The median age was 6 months for the treated patients and 8 months for the patients not receiving radiotherapy. In the group treated with radium-226 or orthovoltage x rays (doubt)>100-kV peak),doubt>, 224 cancers were observed (relative risk (RR)=1.18; 95% confidence interval (CD)=1.03–1.35). In patients given contact x rays, 10 cancers were observed (RR=0.71; 95% CI=0.34–1.30). In patients not treated with ionizing radiation, 34 cancers were observed (RR=0.93; 95% CI=0.64–1.29). In patients treated with radium-226 or orthovoltage x rays, an RR of 1.65 was observed for breast cancer (95%CI=1.26–2.13) and an RR of 2.73 was found for soft tissue tumors, (95%CI = 1.18–5.38). Patients with brain tumors, thyroid cancers, and bone tumors had received radiotherapy close to the tumor ate more often than expected. For patients with breast cancer, no such difference was found. For cancers of the breast and thyroid, the RR was higher in patients given more than one treatment. [J Natl Cancer Inst 1988;80:1387–1392]
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/80.17.1387